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CSF tau phosphoryla...
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
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- Barthélemy, Nicolas R. (author)
- Washington University in St. Louis
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- Saef, Benjamin (author)
- Washington University in St. Louis
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- Li, Yan (author)
- Washington University in St. Louis
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- Gordon, Brian A. (author)
- Washington University in St. Louis
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- He, Yingxin (author)
- Washington University in St. Louis
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- Horie, Kanta (author)
- Washington University in St. Louis
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- Stomrud, Erik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Salvadó, Gemma (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Janelidze, Shorena (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Sato, Chihiro (author)
- Washington University in St. Louis
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- Ovod, Vitaliy (author)
- Washington University in St. Louis
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- Henson, Rachel L. (author)
- Washington University in St. Louis
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- Fagan, Anne M. (author)
- Washington University in St. Louis
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- Benzinger, Tammie L.S. (author)
- Washington University in St. Louis
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- Xiong, Chengjie (author)
- Washington University in St. Louis
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- Morris, John C. (author)
- Washington University in St. Louis
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Bateman, Randall J. (author)
- Washington University in St. Louis
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- Schindler, Suzanne E. (author)
- Washington University in St. Louis
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Washington University in St Louis Klinisk minnesforskning (creator_code:org_t)
- 2023-03-13
- 2023
- English 11 s.
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In: Nature Aging. - : Springer Science and Business Media LLC. - 2662-8465. ; 3:4, s. 391-401
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer’s disease (AD). The present study used mass spectrometry to measure concentrations of nine phosphorylated and five nonphosphorylated tau species and phosphorylation occupancies (percentage phosphorylated/nonphosphorylated) at ten sites. In the present study we show that, in 750 individuals with a median age of 71.2 years, CSF pT217/T217 predicted the presence of brain amyloid by positron emission tomography (PET) slightly better than Aβ42/Aβ40 (P = 0.02). Furthermore, for individuals with positive brain amyloid by PET (n = 263), CSF pT217/T217 was more strongly correlated with the amount of amyloid (Spearman’s ρ = 0.69) than Aβ42/Aβ40 (ρ = −0.42, P < 0.0001). In two independent cohorts of participants with symptoms of AD dementia (n = 55 and n = 90), CSF pT217/T217 and pT205/T205 were better correlated with tau PET measures than CSF p-tau181 concentration. These findings suggest that CSF pT217/T217 and pT205/T205 represent improved CSF biomarkers of amyloid and tau pathology in AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Barthélemy, Nico ...
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Saef, Benjamin
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Li, Yan
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Gordon, Brian A.
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He, Yingxin
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Horie, Kanta
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show more...
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Stomrud, Erik
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Salvadó, Gemma
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Janelidze, Shore ...
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Sato, Chihiro
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Ovod, Vitaliy
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Henson, Rachel L ...
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Fagan, Anne M.
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Benzinger, Tammi ...
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Xiong, Chengjie
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Morris, John C.
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Hansson, Oskar
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Bateman, Randall ...
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Schindler, Suzan ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Aging
- By the university
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Lund University