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The secondary bile ...
The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery
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- Louca, Panayiotis (author)
- King's College London
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- Meijnikman, Abraham S. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Nogal, Ana (author)
- King's College London
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- Asnicar, Francesco (author)
- University of Trento
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- Attaye, Ilias (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Vijay, Amrita (author)
- University of Nottingham
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- Kouraki, Afroditi (author)
- University of Nottingham
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- Visconti, Alessia (author)
- King's College London
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- Wong, Kari (author)
- Metabolon Inc.
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- Berry, Sarah E. (author)
- King's College London
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- Leeming, Emily R. (author)
- King's College London
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- Mompeo, Olatz (author)
- King's College London
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- Tettamanzi, Francesca (author)
- King's College London
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- Baleanu, Andrei Florin (author)
- King's College London
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- Falchi, Mario (author)
- King's College London
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- Hadjigeorgiou, George (author)
- Zoe Global Limited
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- Wolf, Jonathan (author)
- Zoe Global Limited
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- Acherman, Yair I.Z. (author)
- Spaarne Gasthuis Hospital
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- Van de Laar, Arnold W. (author)
- Spaarne Gasthuis Hospital
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- Gerdes, Victor E.A. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Michelotti, Gregory A. (author)
- Metabolon Inc.
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genetic and Molecular Epidemiology
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- Segata, Nicola (author)
- University of Trento
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- Mangino, Massimo (author)
- Guy's and St Thomas' NHS Foundation Trust,King's College London
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- Spector, Tim D. (author)
- King's College London
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- Bulsiewicz, William J. (author)
- Zoe Global Limited
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- Nieuwdorp, Max (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Valdes, Ana M. (author)
- University of Nottingham
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- Menni, Cristina (author)
- King's College London
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Cell Reports Medicine. - 2666-3791. ; 4:4
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional interventions. We report that BAs have a moderately heritable genetic component, and the gut microbiome accurately predicts their levels in serum and stool. The secondary BA isoursodeoxycholate (isoUDCA) can be explained mostly by gut microbes (area under the receiver operating characteristic curve [AUC] = ∼80%) and associates with post-prandial lipemia and inflammation (GlycA). Furthermore, circulating isoUDCA decreases significantly 1 year after bariatric surgery (β = −0.72, p = 1 × 10−5) and in response to fiber supplementation (β = −0.37, p < 0.03) but not omega-3 supplementation. In healthy individuals, isoUDCA fasting levels correlate with pre-meal appetite (p < 1 × 10−4). Our findings indicate an important role for isoUDCA in lipid metabolism, appetite, and, potentially, cardiometabolic risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- bariatric surgery
- bile acids
- liver function
- post-prandial
- triglycerides
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Louca, Panayioti ...
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Meijnikman, Abra ...
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Nogal, Ana
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Asnicar, Frances ...
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Attaye, Ilias
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Vijay, Amrita
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show more...
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Kouraki, Afrodit ...
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Visconti, Alessi ...
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Wong, Kari
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Berry, Sarah E.
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Leeming, Emily R ...
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Mompeo, Olatz
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Tettamanzi, Fran ...
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Baleanu, Andrei ...
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Falchi, Mario
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Hadjigeorgiou, G ...
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Wolf, Jonathan
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Acherman, Yair I ...
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Van de Laar, Arn ...
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Gerdes, Victor E ...
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Michelotti, Greg ...
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Franks, Paul W.
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Segata, Nicola
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Mangino, Massimo
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Spector, Tim D.
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Bulsiewicz, Will ...
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Nieuwdorp, Max
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Valdes, Ana M.
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Menni, Cristina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Cell Reports Med ...
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Lund University