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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05248naa a2200841 4500 | |
| 001 | oai:lup.lub.lu.se:4a69a42e-cdce-4462-a2ba-9027d0a7676d | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-18819 | |
| 024 | 7 | a https://lup.lub.lu.se/record/6747272 URI |
| 024 | 7 | a https://doi.org/10.1093/carcin/bgl1592 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-188192 URI |
| 040 | a (SwePub)lud (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Manuguerra, M.4 aut |
| 245 | 1 0 | a Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions |
| 264 | c 2006-07-08 | |
| 264 | 1 | b Oxford University Press (OUP),c 2007 |
| 520 | a It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 controls and 409 cases with bladder cancer (n = 124), lung cancer (n = 116) and myeloid leukemia (n = 169). Thirty-six gene variants (DNA repair and metabolic genes) and three environmental exposure variables (measures of air pollution and ETS at home and at work) were analyzed. Interactions were assessed by prediction error percentage and cross-validation consistency (CVC) frequency. For lung cancer, the best model was given by a significant gene-environment association between the base excision repair (BER) XRCC1-Arg399Gln polymorphism, the double-strand break repair (DSBR) BRCA2-Asn372His polymorphism and the exposure variable 'distance from heavy traffic road', an indirect and robust indicator of air pollution (mean prediction error of 26%, P < 0.001, mean CVC of 6.60, P = 0.02). For bladder cancer, we found a significant 4-loci association between the BER APE1-Asp148Glu polymorphism, the DSBR RAD52-3'-untranslated region (3'-UTR) polymorphism and the metabolic gene polymorphisms COMT-Val158Met and MTHFR-677C > T (mean prediction error of 22%, P < 0.001, mean CVC consistency of 7.40, P < 0.037). For leukemia, a 3-loci model including RAD52-2259C > T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P < 0.001) and a maximum CVC of 4.40 (P = 0.086). The MDR method seems promising, because it provides a limited number of statistically stable interactions; however, the biological interpretation remains to be understood. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Matullo, G.4 aut |
| 700 | 1 | a Veglia, F.4 aut |
| 700 | 1 | a Autrup, H.4 aut |
| 700 | 1 | a Dunning, A. M.4 aut |
| 700 | 1 | a Garte, S.4 aut |
| 700 | 1 | a Gormally, E.4 aut |
| 700 | 1 | a Malaveille, C.4 aut |
| 700 | 1 | a Guarrera, S.4 aut |
| 700 | 1 | a Polidoro, S.4 aut |
| 700 | 1 | a Saletta, F.4 aut |
| 700 | 1 | a Peluso, M.4 aut |
| 700 | 1 | a Airoldi, L.4 aut |
| 700 | 1 | a Overvad, K.4 aut |
| 700 | 1 | a Raaschou-Nielsen, O.4 aut |
| 700 | 1 | a Clavel-Chapelon, F.4 aut |
| 700 | 1 | a Linseisen, J.4 aut |
| 700 | 1 | a Boeing, H.4 aut |
| 700 | 1 | a Trichopoulos, D.4 aut |
| 700 | 1 | a Kalandidi, A.4 aut |
| 700 | 1 | a Palli, D.4 aut |
| 700 | 1 | a Krogh, V.4 aut |
| 700 | 1 | a Tumino, R.4 aut |
| 700 | 1 | a Panico, S.4 aut |
| 700 | 1 | a Bueno-De-Mesquita, H. B.4 aut |
| 700 | 1 | a Peeters, P. H.4 aut |
| 700 | 1 | a Lund, E.4 aut |
| 700 | 1 | a Pera, G.4 aut |
| 700 | 1 | a Martinez, C.4 aut |
| 700 | 1 | a Amiano, P.4 aut |
| 700 | 1 | a Barricarte, A.4 aut |
| 700 | 1 | a Tormo, M. J.4 aut |
| 700 | 1 | a Quiros, J. R.4 aut |
| 700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
| 700 | 1 | a Janzon, L.4 aut |
| 700 | 1 | a Jarvholm, Bu Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)beja0001 |
| 700 | 1 | a Day, N. E.4 aut |
| 700 | 1 | a Allen, N. E.4 aut |
| 700 | 1 | a Saracci, R.4 aut |
| 700 | 1 | a Kaaks, R.4 aut |
| 700 | 1 | a Ferrari, P.4 aut |
| 700 | 1 | a Riboli, E.4 aut |
| 700 | 1 | a Vineis, P.4 aut |
| 710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Carcinogenesisd : Oxford University Press (OUP)g 28:2, s. 414-422q 28:2<414-422x 0143-3334x 1460-2180 |
| 856 | 4 | u http://dx.doi.org/10.1093/carcin/bgl159x freey FULLTEXT |
| 856 | 4 | u https://academic.oup.com/carcin/article-pdf/28/2/414/7515260/bgl159.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/674727 |
| 856 | 4 8 | u https://doi.org/10.1093/carcin/bgl159 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18819 |
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- Gormally, E.
- Malaveille, C.
- Guarrera, S.
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- Quiros, J. R.
- Berglund, Göran
- Janzon, L.
- Jarvholm, B
- Day, N. E.
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- Kaaks, R.
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