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The neutrophil-mobi...
The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers
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- Che, Karlhans Fru (author)
- Karolinska Institutet,Karolinska Institute
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- Tufvesson, Ellen (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lungfysiologi och biomarkörer,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lung physiology and biomarkers,Lund University Research Groups
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- Tengvall, Sara (author)
- Sahlgrenska Academy
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- Lappi-Blanco, Elisa (author)
- Oulu University Hospital
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- Kaarteenaho, Riitta (author)
- Oulu University Hospital
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- Levänen, Bettina (author)
- Karolinska Institutet,Karolinska Institute
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- Ekberg, Marie (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Brauner, Annelie (author)
- Karolinska Institutet,Karolinska University Hospital
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- Wheelock, Åsa M. (author)
- Karolinska Institutet,Karolinska Institute
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- Bjermer, Leif (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Magnus Sköld, C. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Lindén, Anders (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2018
- 2018
- English 25 s.
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In: Clinical Science. - 0143-5221. ; 132:9, s. 959-983
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Abstract
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- Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26 (IL-26) is involved in airway inflammation amongst long-term tobacco smokers with or without COPD, chronic bronchitis or colonization by pathogenic bacteria. By analyzing bronchoalveolar lavage (BAL), bronchail wash (BW) and induced sputum (IS) samples, we found increased extracellular IL-26 protein in the airways of long-term smokers in vivo without further increase amongst those with clinically stable COPD. In human alveolar macrophages (AM) in vitro, the exposure to water-soluble tobacco smoke components (WTC) enhanced IL-26 gene and protein. In this cell model, the same exposure increased gene expression of the IL-26 receptor complex (IL10R2 and IL20R1) and nuclear factor κ B (NF-κB); a proven regulator of IL-26 production. In the same cell model, recombinant human IL-26 in vitro caused a concentration-dependent increase in the gene expression of NF-κB and several pro-inflammatory cytokines. In the long-term smokers, we also observed that extracellular IL-26 protein in BAL samples correlates with measures of lung function, tobacco load, and several markers of neutrophil accumulation. Extracellular IL-26 was further increased in long-term smokers with exacerbations of COPD (IS samples), with chronic bronchitis (BAL samples ) or with colonization by pathogenic bacteria (IS and BW samples). Thus, IL-26 in the airways emerges as a promising target for improving the understanding of the pathogenic mechanisms behind several pulmonary morbidities in long-term tobacco smokers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Che, Karlhans Fr ...
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Tufvesson, Ellen
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Tengvall, Sara
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Lappi-Blanco, El ...
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Kaarteenaho, Rii ...
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Levänen, Bettina
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show more...
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Ekberg, Marie
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Brauner, Annelie
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Wheelock, Åsa M.
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Bjermer, Leif
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Magnus Sköld, C.
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Lindén, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Clinical Science
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Clinical science ...
- By the university
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Lund University
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Karolinska Institutet