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Refinement of breast cancer molecular classification by miRNA expression profiles

Søkilde, Rolf (author)
Lund University,Lunds universitet,Cancer och icke-kodande RNA,Forskargrupper vid Lunds universitet,Cancer and non coding RNA,Lund University Research Groups
Persson, Helena (author)
Lund University,Lunds universitet,Cancer och icke-kodande RNA,Forskargrupper vid Lunds universitet,Cancer and non coding RNA,Lund University Research Groups
Ehinger, Anna (author)
Skåne University Hospital
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Pirona, Anna Chiara (author)
Lund University,German Cancer Research Centre
Fernö, Mårten (author)
Lund University,Lunds universitet,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,Personalized Breast Cancer Treatment,Lund University Research Groups
Hegardt, Cecilia (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Larsson, Christer (author)
Lund University,Lunds universitet,Tumörcellsbiologi,Forskargrupper vid Lunds universitet,Tumor Cell Biology,Lund University Research Groups
Loman, Niklas (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Malmberg, Martin (author)
Skåne University Hospital
Rydén, Lisa (author)
Lund University,Lunds universitet,Skåne University Hospital
Saal, Lao (author)
Lund University,Lunds universitet,Translational Oncogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
Borg, Åke (author)
Lund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Familial Breast Cancer,Lund University Research Groups
Vallon-Christerson, Johan (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Rovira, Carlos (author)
Lund University,Lunds universitet,Cancer och icke-kodande RNA,Forskargrupper vid Lunds universitet,Cancer and non coding RNA,Lund University Research Groups
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 (creator_code:org_t)
2019-06-17
2019
English 12 s.
In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 20:1
Related links:
http://dx.doi.org/10... (free)
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https://bmcgenomics....
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Accurate classification of breast cancer using gene expression profiles has contributed to a better understanding of the biological mechanisms behind the disease and has paved the way for better prognostication and treatment prediction.RESULTS: We found that miRNA profiles largely recapitulate intrinsic subtypes. In the case of HER2-enriched tumors a small set of miRNAs including the HER2-encoded mir-4728 identifies the group with very high specificity. We also identified differential expression of the miR-99a/let-7c/miR-125b miRNA cluster as a marker for separation of the Luminal A and B subtypes. High expression of this miRNA cluster is linked to better overall survival among patients with Luminal A tumors. Correlation between the miRNA cluster and their precursor LINC00478 is highly significant suggesting that its expression could help improve the accuracy of present day's signatures.CONCLUSIONS: We show here that miRNA expression can be translated into mRNA profiles and that the inclusion of miRNA information facilitates the molecular diagnosis of specific subtypes, in particular the clinically relevant sub-classification of luminal tumors.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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