Search: onr:"swepub:oai:lup.lub.lu.se:4b9926fd-05d3-4adc-96c8-12e32af3cda2" > Contribution of kno...
Fältnamn | Indikatorer | Metadata |
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000 | 05623naa a2200709 4500 | |
001 | oai:lup.lub.lu.se:4b9926fd-05d3-4adc-96c8-12e32af3cda2 | |
003 | SwePub | |
008 | 160401s2002 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1153942 URI |
024 | 7 | a https://doi.org/10.2337/diabetes.51.5.16092 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Lindgren, Ceciliau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)endo-cli |
245 | 1 0 | a Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity. |
264 | 1 | b American Diabetes Association,c 2002 |
520 | a In an attempt to identify novel susceptibility genes predisposing to early-onset diabetes (EOD), we performed a genome-wide scan using 433 markers in 222 individuals (119 with diabetes) from 29 Scandinavian families with ≥2 members with onset of diabetes ≤45 years. The highest nonparametric linkage (NPL) score, 2.7 (P < 0.01), was observed on chromosome 1p (D1S473/D1S438). Six other regions on chromosomes 3p, 7q, 11q, 18q, 20q, and 21q showed a nominal P value <0.05. Of the EOD subjects in these 29 families, 20% were GAD antibody positive and 68% displayed type 1 diabetes HLA risk alleles (DQB*02 or 0302). Mutations in maturity-onset diabetes of the young (MODY) 1–5 genes and the A3243G mitochondrial DNA mutation were detected by single-strand conformation polymorphism and direct sequencing. To increase homogeneity, we analyzed a subsample of five families with autosomal dominant inheritance of EOD (greater than or equal to two members with age at diagnosis ≤35 years). The highest NPL scores were found on chromosome 1p (D1S438–D1S1665; NPL 3.0; P < 0.01) and 16q (D16S419; NPL 2.9; P < 0.01). After exclusion of three families with MODY1, MODY3, and mitochondrial mutations, the highest NPL scores were observed on chromosomes 1p (D1S438; NPL 2.6; P < 0.01), 3p (D3S1620; NPL 2.2; P < 0.03), 5q (D5S1465; NPL 2.1; P < 0.03), 7q (D7S820; NPL 2.0; P < 0.03), 18q (D18S535; NPL 1.9; P < 0.04), 20q (D20S195; NPL 2.5; P < 0.02), and 21q (D21S1446; NPL 2.2; P < 0.03). We conclude that considerable heterogeneity exists in Scandinavian subjects with EOD; 24% had MODY or maternally inherited diabetes and deafness, and ∼60% were GAD antibody positive or had type 1 diabetes-associated HLA genotypes. Our data also point at putative chromosomal regions, which could harbor novel genes that contribute to EOD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Human | |
653 | a Genome | |
653 | a Genetic Screening | |
653 | a Genetic Predisposition to Disease | |
653 | a Genetic Markers | |
653 | a Genetic Heterogeneity | |
653 | a Female | |
653 | a Insulin-Dependent: genetics | |
653 | a Adult | |
653 | a Diabetes Mellitus | |
653 | a Biological Markers | |
653 | a Autoantibodies: blood | |
653 | a Aged | |
653 | a Age of Onset | |
653 | a Insulin-Dependent: immunology | |
653 | a Family Health | |
653 | a Genotype | |
653 | a HLA-DQ Antigens: genetics | |
653 | a Male | |
653 | a Middle Age | |
653 | a Mutation | |
653 | a Pedigree | |
653 | a Scandinavia | |
653 | a Support | |
653 | a Non-U.S. Gov't | |
700 | 1 | a Widén, Elisabeth4 aut |
700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)ti8736tu |
700 | 1 | a Li, Haiyanu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)endo-hli |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Kanninen, Timo4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Weng, Jianping4 aut |
700 | 1 | a Lehto, Markku4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
710 | 2 | a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 51:5, s. 1609-1617q 51:5<1609-1617x 1939-327Xx 0012-1797 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11978663&dopt=Abstractx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.2337/diabetes.51.5.1609x freey FULLTEXT |
856 | 4 | u http://diabetes.diabetesjournals.org/content/51/5/1609.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/115394 |
856 | 4 8 | u https://doi.org/10.2337/diabetes.51.5.1609 |
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