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Genome-wide associa...
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2007
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:4c3f4bd1-ec53-4b36-a53c-564bc07ba43c
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https://lup.lub.lu.se/record/663952URI
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https://doi.org/10.1126/science.1142358DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Voight, Benjamin F.
(author)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
(author)
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Burtt, Noel P.
(author)
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de Bakker, Paul I. W.
(author)
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Chen, Hong
(author)
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Roix, Jeffrey J.
(author)
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Kathiresan, Sekar
(author)
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Hirschhorn, Joel N.
(author)
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Daly, Mark J.
(author)
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Hughes, Thomas E.
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Altshuler, David
(author)
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Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal
(author)
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Florez, Jose C.
(author)
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Meyer, Joanne
(author)
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Ardlie, Kristin
(author)
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Bengtsson Boström, KristinaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)smi-kb0
(author)
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Isomaa, Bo
(author)
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Lettre, Guillaume
(author)
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Lindblad, UlfLund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups(Swepub:lu)smi-uli
(author)
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Lyon, Helen N.
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Newton-Cheh, Christopher
(author)
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Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Råstam, LennartLund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups(Swepub:lu)smi-lra
(author)
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Speliotes, Elizabeth K.
(author)
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Taskinen, Marja-Riitta
(author)
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Tuomi, Tiinamaija
(author)
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Guiducci, Candace
(author)
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Berglund, AnnaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-abe
(author)
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Carlson, JoyceLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-jca
(author)
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Gianniny, Lauren
(author)
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Hackett, Rachel
(author)
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Hall, Liselotte
(author)
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Holmkvist, JohanLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-jho
(author)
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Laurila, EsaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-ela
(author)
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Sjögren, MarketaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension(Swepub:lu)endo-msj
(author)
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Sterner, Maria
(author)
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Surti, Aarti
(author)
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Svensson, MargaretaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-msv
(author)
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Svensson, MalinLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mab
(author)
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Tewhey, Ryan
(author)
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Blumenstiel, Brendan
(author)
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Parkin, Melissa
(author)
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DeFelice, Matthew
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Barry, Rachel
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Brodeur, Wendy
(author)
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Camarata, Jody
(author)
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Chia, Nancy
(author)
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Fava, Mary
(author)
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Gibbons, John
(author)
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Handsaker, Bob
(author)
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Healy, Claire
(author)
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Nguyen, Kieu
(author)
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Gates, Casey
(author)
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Sougnez, Carrie
(author)
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Gage, Diane
(author)
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Nizzari, Marcia
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Gabriel, Stacey B.
(author)
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Chirn, Gung-Wei
(author)
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Ma, Qicheng
(author)
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Parikh, HemangLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-hpa
(author)
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Richardson, Delwood
(author)
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Ricke, Darrell
(author)
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Purcell, Shaun
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Science: American Association for the Advancement of Science (AAAS)316:5829, s. 1331-13361095-92030036-8075
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Saxena, Richa
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Voight, Benjamin ...
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Lyssenko, Valeri ...
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Burtt, Noel P.
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de Bakker, Paul ...
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Chen, Hong
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Roix, Jeffrey J.
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Kathiresan, Seka ...
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Hirschhorn, Joel ...
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Daly, Mark J.
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Hughes, Thomas E ...
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Groop, Leif
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Altshuler, David
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Almgren, Peter
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Florez, Jose C.
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Meyer, Joanne
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Ardlie, Kristin
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Bengtsson Boströ ...
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Isomaa, Bo
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Lettre, Guillaum ...
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Lindblad, Ulf
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Lyon, Helen N.
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Melander, Olle
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Newton-Cheh, Chr ...
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Nilsson, Peter
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Orho-Melander, M ...
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Råstam, Lennart
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Speliotes, Eliza ...
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Taskinen, Marja- ...
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Tuomi, Tiinamaij ...
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Guiducci, Candac ...
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Berglund, Anna
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Carlson, Joyce
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Gianniny, Lauren
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Hackett, Rachel
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Hall, Liselotte
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Holmkvist, Johan
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Laurila, Esa
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Sjögren, Marketa
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Sterner, Maria
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Surti, Aarti
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Svensson, Margar ...
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Svensson, Malin
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Tewhey, Ryan
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Blumenstiel, Bre ...
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Parkin, Melissa
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DeFelice, Matthe ...
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Barry, Rachel
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Brodeur, Wendy
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Camarata, Jody
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Chia, Nancy
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Fava, Mary
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Gibbons, John
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Handsaker, Bob
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Healy, Claire
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Nguyen, Kieu
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Gates, Casey
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Sougnez, Carrie
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Gage, Diane
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Nizzari, Marcia
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Gabriel, Stacey ...
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Chirn, Gung-Wei
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Ma, Qicheng
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Parikh, Hemang
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Richardson, Delw ...
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Ricke, Darrell
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Purcell, Shaun
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