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Insight into the Ma...
Insight into the Mammalian Aquaporin Interactome
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- Törnroth-Horsefield, Susanna (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Chivasso, Clara (author)
- Université Libre de Bruxelles (ULB)
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- Strandberg, Helin (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- D’Agostino, Claudia (author)
- Université Libre de Bruxelles (ULB)
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- O’Neale, Carla V.T. (author)
- Vanderbilt University
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- Schey, Kevin L. (author)
- Vanderbilt University
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- Delporte, Christine (author)
- Université Libre de Bruxelles (ULB)
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(creator_code:org_t)
- 2022-08-25
- 2022
- English.
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In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:17
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein–protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein–protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- aquaporin
- function
- interactome
- mammalian
- protein–protein interaction
- trafficking
Publication and Content Type
- for (subject category)
- ref (subject category)
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