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Mortality and HRQoL...
Mortality and HRQoL in ICU patients with delirium : Protocol for 1-year follow-up of AID-ICU trial
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- Mortensen, Camilla B. (author)
- Region Hospital Køge
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- Poulsen, Lone M. (author)
- CRIC - Collaboration for Research in Intensive Care
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- Andersen-Ranberg, Nina C. (author)
- CRIC - Collaboration for Research in Intensive Care,Region Hospital Køge
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- Perner, Anders (author)
- University of Copenhagen,CRIC - Collaboration for Research in Intensive Care,Copenhagen University Hospital
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- Lange, Theis (author)
- University of Copenhagen,CRIC - Collaboration for Research in Intensive Care
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- Estrup S, Stine (author)
- Region Hospital Køge
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- Ebdrup, Bjørn H. (author)
- University of Copenhagen
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- Egerod, Ingrid (author)
- University of Copenhagen,CRIC - Collaboration for Research in Intensive Care,Copenhagen University Hospital
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- Rasmussen, Bodil S. (author)
- Aalborg University Hospital
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- Hästbacka, Johanna (author)
- Helsinki University Central Hospital
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- Caballero, Jesús (author)
- Hospital Arnau de Vilanova in Valencia,Autonomous University of Barcelona
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- Citerio, Giuseppe (author)
- University of Wales
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- Morgan, Matthew P.G. (author)
- University of Milano-Bicocca
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- Samuelson, Karin (author)
- Lund University,Lunds universitet,Hälsofrämjande komplexa interventioner,Forskargrupper vid Lunds universitet,Health-promoting Complex Interventions,Lund University Research Groups
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- Mathiesen, Ole (author)
- Aalborg University Hospital,Region Hospital Køge
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(creator_code:org_t)
- 2020-08-16
- 2020
- English 7 s.
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In: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 64:10, s. 1519-1525
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Abstract
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- Background: Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against ICU-acquired delirium. Agents intervening against Delirium in the ICU (AID-ICU) is an international, multicentre, randomised, blinded, placebo-controlled trial investigates benefits and harms of treatment with haloperidol in patients with ICU-acquired delirium. The current pre-planned one-year follow-up study of the AID-ICU trial population aims to explore the effects of haloperidol on one-year mortality and health related quality of life (HRQoL). Methods : The AID-ICU trial will include 1000 participants. One-year mortality will be obtained from the trial sites; we will validate the vital status of Danish participants using the Danish National Health Data Registers. Mortality will be analysed by Cox-regression and visualized by Kaplan-Meier curves tested for significance using the log-rank test. We will obtain HRQoL data using the EQ-5D instrument. HRQoL analysis will be performed using a general linear model adjusted for stratification variables. Deceased participants will be designated the worst possible value. Results: We expect to publish results of this study in 2022. Conclusion: We expect that this one-year follow-up study of participants with ICU-acquired delirium allocated to haloperidol vs. placebo will provide important information on the long-term consequences of delirium including the effects of haloperidol. We expect that our results will improve the care of this vulnerable patient group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Mortensen, Camil ...
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Poulsen, Lone M.
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Andersen-Ranberg ...
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Perner, Anders
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Lange, Theis
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Estrup S, Stine
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show more...
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Ebdrup, Bjørn H.
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Egerod, Ingrid
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Rasmussen, Bodil ...
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Hästbacka, Johan ...
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Caballero, Jesús
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Citerio, Giusepp ...
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Morgan, Matthew ...
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Samuelson, Karin
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Mathiesen, Ole
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Acta Anaesthesio ...
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Lund University