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Mortality and HRQoL...
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Mortensen, Camilla B.Region Hospital Køge
(author)
Mortality and HRQoL in ICU patients with delirium : Protocol for 1-year follow-up of AID-ICU trial
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-08-16
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Wiley,2020
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7 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:4cd07202-97e6-4b13-83bd-a634028dcb20
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https://lup.lub.lu.se/record/4cd07202-97e6-4b13-83bd-a634028dcb20URI
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https://doi.org/10.1111/aas.13679DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Intensive care unit (ICU)-acquired delirium is frequent and associated with poor short- and long-term outcomes for patients in ICUs. It therefore constitutes a major healthcare problem. Despite limited evidence, haloperidol is the most frequently used pharmacological intervention against ICU-acquired delirium. Agents intervening against Delirium in the ICU (AID-ICU) is an international, multicentre, randomised, blinded, placebo-controlled trial investigates benefits and harms of treatment with haloperidol in patients with ICU-acquired delirium. The current pre-planned one-year follow-up study of the AID-ICU trial population aims to explore the effects of haloperidol on one-year mortality and health related quality of life (HRQoL). Methods : The AID-ICU trial will include 1000 participants. One-year mortality will be obtained from the trial sites; we will validate the vital status of Danish participants using the Danish National Health Data Registers. Mortality will be analysed by Cox-regression and visualized by Kaplan-Meier curves tested for significance using the log-rank test. We will obtain HRQoL data using the EQ-5D instrument. HRQoL analysis will be performed using a general linear model adjusted for stratification variables. Deceased participants will be designated the worst possible value. Results: We expect to publish results of this study in 2022. Conclusion: We expect that this one-year follow-up study of participants with ICU-acquired delirium allocated to haloperidol vs. placebo will provide important information on the long-term consequences of delirium including the effects of haloperidol. We expect that our results will improve the care of this vulnerable patient group.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Poulsen, Lone M.CRIC - Collaboration for Research in Intensive Care
(author)
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Andersen-Ranberg, Nina C.CRIC - Collaboration for Research in Intensive Care,Region Hospital Køge
(author)
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Perner, AndersUniversity of Copenhagen,CRIC - Collaboration for Research in Intensive Care,Copenhagen University Hospital
(author)
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Lange, TheisUniversity of Copenhagen,CRIC - Collaboration for Research in Intensive Care
(author)
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Estrup S, StineRegion Hospital Køge
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Ebdrup, Bjørn H.University of Copenhagen
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Egerod, IngridUniversity of Copenhagen,CRIC - Collaboration for Research in Intensive Care,Copenhagen University Hospital
(author)
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Rasmussen, Bodil S.Aalborg University Hospital
(author)
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Hästbacka, JohannaHelsinki University Central Hospital
(author)
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Caballero, JesúsHospital Arnau de Vilanova in Valencia,Autonomous University of Barcelona
(author)
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Citerio, GiuseppeUniversity of Wales
(author)
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Morgan, Matthew P.G.University of Milano-Bicocca
(author)
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Samuelson, KarinLund University,Lunds universitet,Hälsofrämjande komplexa interventioner,Forskargrupper vid Lunds universitet,Health-promoting Complex Interventions,Lund University Research Groups(Swepub:lu)omv-ksa
(author)
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Mathiesen, OleAalborg University Hospital,Region Hospital Køge
(author)
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Region Hospital KøgeCRIC - Collaboration for Research in Intensive Care
(creator_code:org_t)
Related titles
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In:Acta Anaesthesiologica Scandinavica: Wiley64:10, s. 1519-15250001-51721399-6576
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Mortensen, Camil ...
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Poulsen, Lone M.
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Andersen-Ranberg ...
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Perner, Anders
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Lange, Theis
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Estrup S, Stine
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Ebdrup, Bjørn H.
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Egerod, Ingrid
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Rasmussen, Bodil ...
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Hästbacka, Johan ...
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Caballero, Jesús
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Citerio, Giusepp ...
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Morgan, Matthew ...
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Samuelson, Karin
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Mathiesen, Ole
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