A randomised controlled trial of integrated psychological therapy for traumatic stress and substance use among adolescents: Trial protocol

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Mills, KatherineUniversity of Sydney (author)

A randomised controlled trial of integrated psychological therapy for traumatic stress and substance use among adolescents: Trial protocol

Article/chapterEnglish2020

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2020-11-30
BMJ,2020
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LIBRIS-ID:oai:lup.lub.lu.se:4d06820a-53d5-4ee1-a190-e94ea6656a35
https://lup.lub.lu.se/record/4d06820a-53d5-4ee1-a190-e94ea6656a35URI
https://doi.org/10.1136/bmjopen-2020-043742DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Introduction: Post-traumatic stress disorder (PTSD) and substance use disorder frequently co-occur and tend to have their onset during adolescence. Although research has highlighted the importance of treating these disorders in an integrated fashion, there is a dearth of empirically validated integrated treatment options for adolescents with this comorbidity. This paper describes the study protocol for a randomised controlled trial (RCT) examining the efficacy of an integrated trauma-focused cognitive–behavioural treatment for traumatic stress and substance use among adolescents (Concurrent Treatment of PTSD and Substance Use Using Prolonged Exposure - Adolescent (COPE-A)), relative to a supportive counselling control condition (Person-Centred Therapy (PCT)). Methods and analysis: A two-arm, parallel, single-blind RCT with blinded follow-up at 4 and 12 months poststudy entry will be conducted in Sydney, Australia. Participants (n~100 adolescents aged 12–18 years) and their caregivers (caregiver participation is optional) will be allocated to undergo either COPE-A or PCT (allocation ratio 1:1) using minimisation. Both therapies will be delivered individually by project psychologists over a maximum of 16 sessions of 60–90 min duration and will include provision of up to four 30 min optional caregiver sessions. The primary outcome will be between-group differences in change in the severity of PTSD symptoms from baseline to 4-month follow-up, as measured by the Clinician-Administered PTSD Scale for Children and Adolescents for DSM-5. Ethics and dissemination: Ethical approval has been obtained from the human research ethics committees of the Sydney Children’s Hospital Network (HREC/17/SCHN/306) and the University of Sydney (HREC 2018/863). Findings will be published in peer-reviewed journals and presented at scientific conferences. Trial registration number: ACTRN12618000785202; Pre-reults.

Subject headings and genre

SAMHÄLLSVETENSKAP Psykologi hsv//swe
SOCIAL SCIENCES Psychology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
PTSD
Substance use disorders
Children and Adolescents
Randomized Controlled Trial
CBT
Integrated Treatment

Added entries (persons, corporate bodies, meetings, titles ...)

Barrett, EmmaUniversity of Sydney (author)
Back, SudieMedical University of South Carolina (author)
Cobham, VanessaUniversity of Queensland (author)
Bendall, SarahOrygen - National Centre for Excellence in Youth Mental Health (author)
Perrin, SeanLund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences(Swepub:lu)psyc-sep (author)
Brady, KathleenMedical University of South Carolina (author)
Ross, JoanneNational Drug & Alcohol Research Centre,University of New South Wales (author)
Peach, NatalieUniversity of Sydney (author)
Kihas, IvanaUniversity of Sydney (author)
Cassar, JoanneUniversity of Sydney (author)
Schollar-Root, OliviaUniversity of Sydney (author)
Teesson, MareeUniversity of Sydney (author)
University of SydneyMedical University of South Carolina (creator_code:org_t)

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In:BMJ Open: BMJ102044-6055

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By the author/editor: Mills, Katherine; Barrett, Emma; Back, Sudie; Cobham, Vanessa; Bendall, Sarah; Perrin, Sean; show more...; Brady, Kathleen; Ross, Joanne; Peach, Natalie; Kihas, Ivana; Cassar, Joanne; Schollar-Root, O ...; Teesson, Maree; show less...

About the subject

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: BMJ Open

By the university: Lund University

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