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  • Christakoudi, SofiaKing's College London,Imperial College London (author)

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

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  • LIBRIS-ID:oai:lup.lub.lu.se:4d170e28-b4e4-4126-8b29-15df64a65d36
  • https://lup.lub.lu.se/record/4d170e28-b4e4-4126-8b29-15df64a65d36URI
  • https://doi.org/10.1186/s12885-023-11056-1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tsilidis, Konstantinos K.University of Ioannina,Imperial College London (author)
  • Dossus, LaureInternational Agency for Research on Cancer, World Health Organization (author)
  • Rinaldi, SabinaInternational Agency for Research on Cancer, World Health Organization (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (author)
  • Antoniussen, Christian S.Aarhus University (author)
  • Dahm, Christina C.Aarhus University (author)
  • Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society (author)
  • Mellemkjær, LeneDanish Cancer Society (author)
  • Katzke, VerenaGerman Cancer Research Centre (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Schulze, Matthias B.University of Potsdam,German Institute of Human Nutrition (author)
  • Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Grioni, SaraIstituto Nazionale dei Tumori (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Tumino, RosarioHyblean Association for Epidemiological Research (author)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • May, Anne M.University Medical Center Utrecht (author)
  • Monninkhof, Evelyn M.University Medical Center Utrecht (author)
  • Quirós, J. Ramón (author)
  • Bonet, CatalinaCatalan Institute of Oncology,Bellvitge Biomedical Research Institute (author)
  • Sánchez, Maria JoseCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada (author)
  • Amiano, PilarCIBER Epidemiology and Public Health (CIBERESP),Ministry of Health of the Basque Government,Biodonostia Health Research Institute (author)
  • Chirlaque, María DoloresUniversity of Murcia,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Guevara, MarcelaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA) (author)
  • Rosendahl, Ann H.Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breastcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onk-aro (author)
  • Stocks, TanjaLund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-tss (author)
  • Perez-Cornago, AuroraUniversity of Oxford (author)
  • Tin Tin, SandarUniversity of Oxford (author)
  • Heath, Alicia K.Imperial College London (author)
  • Aglago, Elom K.Imperial College London (author)
  • Peruchet-Noray, LaiaUniversity of Barcelona,International Agency for Research on Cancer, World Health Organization (author)
  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (author)
  • Riboli, ElioImperial College London (author)
  • King's College LondonImperial College London (creator_code:org_t)

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  • In:BMC Cancer23:11471-2407

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