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- Blunk, IngaLeibniz Institute for the Biology of Farm Animals (FBN) (author)
Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-07-14
- Springer Science and Business Media LLC,2020
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- LIBRIS-ID:oai:lup.lub.lu.se:4d928c3f-603a-433b-bad5-897b7612fbc4
- https://lup.lub.lu.se/record/4d928c3f-603a-433b-bad5-897b7612fbc4URI
- https://doi.org/10.1038/s41598-020-68212-xDOI
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- Language:English
- Summary in:English
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- Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00% (± 2.00%) and 15.00% (± 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D (P = 1.60 × 10−24) and for RA (P = 0.02). For the first time, the existence of maternal genetic effects on RA was indicated, contributing up to 16.00% (± 3.00%) of the total variance. Environmental factors such as the social economic index, the number of offspring, birth year as well as their interactions with sex showed large effects.
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- Thomsen, HaukeGerman Cancer Research Centre,Genewerk GmbH(Swepub:lu)med-hth (author)
- Reinsch, NorbertLeibniz Institute for the Biology of Farm Animals (FBN) (author)
- Mayer, ManfredLeibniz Institute for the Biology of Farm Animals (FBN) (author)
- Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Hopp Children’s Cancer Center Heidelberg (KiTZ)(Swepub:lu)med-asf (author)
- Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai(Swepub:lu)med-jsu (author)
- Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University(Swepub:lu)med-ksq (author)
- Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Charles University in Prague(Swepub:lu)med-khk (author)
- Leibniz Institute for the Biology of Farm Animals (FBN)German Cancer Research Centre (creator_code:org_t)
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- In:Scientific Reports: Springer Science and Business Media LLC10:12045-2322
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