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Hyponatremia, hyper...
Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains
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- Norello, D. (author)
- University of Florence
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- Rastrelli, G. (author)
- University of Florence
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- Antonio, L. (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Bartfai, G. (author)
- University of Szeged
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- Casanueva, F. F. (author)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
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- Giwercman, A. (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Huhtaniemi, I. T. (author)
- Imperial College London
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- O’Neill, T. W. (author)
- Centre for Epidemiology Versus Arthritis
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- Punab, M. (author)
- Tartu University Hospital
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- Slowikowska-Hilczer, J. (author)
- Medical University of Lodz
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- Tournoy, J. (author)
- University Hospitals Leuven
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- Vanderschueren, D. (author)
- University Hospitals Leuven,Catholic University of Leuven
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- Wu, F. C.W. (author)
- Manchester University NHS Foundation Trust
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- Maggi, M. (author)
- University of Florence
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- Peri, A. (author)
- University of Florence
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Endocrinological Investigation. - 0391-4097.
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http://dx.doi.org/10... (free)
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Abstract
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- Objective: To determine the influence of serum sodium on physical, psychologic and sexual function. Methods: This is a cross-sectional survey on 3340 community-dwelling men aged 40–79 years from a prospective cohort study in eight European countries, the European Male Ageing Study (EMAS). Participants filled-out the Short Form-36 (SF-36), the Physical Activity Scale for the Elderly (PASE), and the EMAS sexual function questionnaire. For all the analyses, serum sodium corrected for glycaemia ([Na+]G) was used. Results: The relationship between [Na+]G and SF-36 physical function score (F = 3.99; p = 0.01), SF-36 mental health score (F = 7.69; p < 0.001), and PASE score (F = 14.95; p < 0.001) were best described by a quadratic equation, with worse scores for [Na+]G in either the lowest or the highest ends of the range. After dividing the sample into [Na+]G < 136 mmol/L (n = 81), 136–147 mmol/L (n = 3223) and > 147 mmol/L (n = 36), linear regression analyses with linear spline functions adjusted for confounders did not confirm these relationships. Similarly, erectile dysfunction and [Na+]G, were in a quadratic relationship (F = 9.00; p < 0.001). After adjusting for confounders, the linear regression with spline functions denoted a significantly worsened erectile function for increases in serum [Na+]G > 147 mmol/L (B = 0.15 [0.04;0.26], p < 0.01) but no relationship with [Na+]G < 136 mmol/L. Likewise, the relationship of [Na+]G with concerns about sexual dysfunction was confirmed only for men with serum [Na+]G > 147 mmol/L. Conclusions: This is the first study supporting an association between [Na+]G and sexual function. A worsening of erection and concerns about sexual function were observed for the highest values of [Na+]G, independently of other relevant factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Erectile dysfunction
- Hypernatremia
- Hyponatremia
- Physical function
- Psychologic function
- Sexual function
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Norello, D.
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Rastrelli, G.
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Antonio, L.
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Bartfai, G.
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Casanueva, F. F.
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Giwercman, A.
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show more...
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Huhtaniemi, I. T ...
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O’Neill, T. W.
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Punab, M.
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Slowikowska-Hilc ...
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Tournoy, J.
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Vanderschueren, ...
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Wu, F. C.W.
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Maggi, M.
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Peri, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Journal of Endoc ...
- By the university
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Lund University