Search: onr:"swepub:oai:lup.lub.lu.se:4dfb7a40-0d3c-455b-88dc-e5f7bb96539c" >
Lack of Association...
-
Assimes, Themistocles L.
(author)
Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- Article/chapterEnglish2010
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:4dfb7a40-0d3c-455b-88dc-e5f7bb96539c
-
https://lup.lub.lu.se/record/1720290URI
-
https://doi.org/10.1016/j.jacc.2010.06.022DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Holm, Hilma
(author)
-
Kathiresan, Sekar
(author)
-
Reilly, Muredach P.
(author)
-
Thorleifsson, Gudmar
(author)
-
Voight, Benjamin F.
(author)
-
Erdmann, Jeanette
(author)
-
Willenborg, Christina
(author)
-
Vaidya, Dhananjay
(author)
-
Xie, Changchun
(author)
-
Patterson, Chris C.
(author)
-
Morgan, Thomas M.
(author)
-
Burnett, Mary Susan
(author)
-
Li, Mingyao
(author)
-
Hlatky, Mark A.
(author)
-
Knowles, Joshua W.
(author)
-
Thompson, John R.
(author)
-
Absher, Devin
(author)
-
Iribarren, Carlos
(author)
-
Go, Alan
(author)
-
Fortmann, Stephen P.
(author)
-
Sidney, Stephen
(author)
-
Risch, Neil
(author)
-
Tang, Hua
(author)
-
Myers, Richard M.
(author)
-
Berger, Klaus
(author)
-
Stoll, Monika
(author)
-
Shah, Svati H.
(author)
-
Thorgeirsson, Gudmundur
(author)
-
Andersen, Karl
(author)
-
Havulinna, Aki S.
(author)
-
Herrera, J. Enrique
(author)
-
Faraday, Nauder
(author)
-
Kim, Yoonhee
(author)
-
Kral, Brian G.
(author)
-
Mathias, Rasika A.
(author)
-
Ruczinski, Ingo
(author)
-
Suktitipat, Bhoom
(author)
-
Wilson, Alexander F.
(author)
-
Yanek, Lisa R.
(author)
-
Becker, Lewis C.
(author)
-
Linsel-Nitschke, Patrick
(author)
-
Lieb, Wolfgang
(author)
-
Koenig, Inke R.
(author)
-
Hengstenberg, Christian
(author)
-
Fischer, Marcus
(author)
-
Stark, Klaus
(author)
-
Reinhard, Wibke
(author)
-
Winogradow, Janina
(author)
-
Grassl, Martina
(author)
-
Grosshennig, Anika
(author)
-
Preuss, Michael
(author)
-
Schreiber, Stefan
(author)
-
Wichmann, H-Erich
(author)
-
Meisinger, Christa
(author)
-
Yee, Jean
(author)
-
Friedlander, Yechiel
(author)
-
Do, Ron
(author)
-
Meigs, James B.
(author)
-
Williams, Gordon
(author)
-
Nathan, David M.
(author)
-
MacRae, Calum A.
(author)
-
Qu, Liming
(author)
-
Wilensky, Robert L.
(author)
-
Matthai, William H., Jr.
(author)
-
Qasim, Atif N.
(author)
-
Hakonarson, Hakon
(author)
-
Pichard, Augusto D.
(author)
-
Kent, Kenneth M.
(author)
-
Satler, Lowell
(author)
-
Lindsay, Joseph M.
(author)
-
Waksman, Ron
(author)
-
Knouff, Christopher W.
(author)
-
Waterworth, Dawn M.
(author)
-
Walker, Max C.
(author)
-
Mooser, Vincent E.
(author)
-
Marrugat, Jaume
(author)
-
Lucas, Gavin
(author)
-
Subirana, Isaac
(author)
-
Sala, Joan
(author)
-
Ramos, Rafael
(author)
-
Martinelli, Nicola
(author)
-
Olivieri, Oliviero
(author)
-
Trabetti, Elisabetta
(author)
-
Malerba, Giovanni
(author)
-
Pignatti, Pier Franco
(author)
-
Guiducci, Candace
(author)
-
Mirel, Daniel
(author)
-
Parkin, Melissa
(author)
-
Hirschhorn, Joel N.
(author)
-
Asselta, Rosanna
(author)
-
Duga, Stefano
(author)
-
Musunuru, Kiran
(author)
-
Daly, Mark J.
(author)
-
Purcell, Shaun
(author)
-
Eifert, Sandra
(author)
-
Braund, Peter S.
(author)
-
Wright, Benjamin J.
(author)
-
Balmforth, Anthony J.
(author)
-
Ball, Stephen G.
(author)
-
Ouwehand, Willem H.
(author)
-
Deloukas, Panos
(author)
-
Scholz, Michael
(author)
-
Cambien, Francois
(author)
-
Huge, Andreas
(author)
-
Scheffold, Thomas
(author)
-
Salomaa, Veikko
(author)
-
Girelli, Domenico
(author)
-
Granger, Christopher B.
(author)
-
Peltonen, Leena
(author)
-
McKeown, Pascal P.
(author)
-
Altshuler, David
(author)
-
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
-
Devaney, Joseph M.
(author)
-
Epstein, Stephen E.
(author)
-
Rader, Daniel J.
(author)
-
Elosua, Roberto
(author)
-
Engert, James C.
(author)
-
Anand, Sonia S.
(author)
-
Hall, Alistair S.
(author)
-
Ziegler, Andreas
(author)
-
O'Donnell, Christopher J.
(author)
-
Spertus, John A.
(author)
-
Siscovick, David
(author)
-
Schwartz, Stephen M.
(author)
-
Becker, Diane
(author)
-
Thorsteinsdottir, Unnur
(author)
-
Stefansson, Kari
(author)
-
Schunkert, Heribert
(author)
-
Samani, Nilesh J.
(author)
-
Quertermous, Thomas
(author)
-
Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Journal of the American College of Cardiology: Elsevier BV56:19, s. 1552-15630735-1097
Internet link
Find in a library
To the university's database
- By the author/editor
-
Assimes, Themist ...
-
Holm, Hilma
-
Kathiresan, Seka ...
-
Reilly, Muredach ...
-
Thorleifsson, Gu ...
-
Voight, Benjamin ...
-
show more...
-
Erdmann, Jeanett ...
-
Willenborg, Chri ...
-
Vaidya, Dhananja ...
-
Xie, Changchun
-
Patterson, Chris ...
-
Morgan, Thomas M ...
-
Burnett, Mary Su ...
-
Li, Mingyao
-
Hlatky, Mark A.
-
Knowles, Joshua ...
-
Thompson, John R ...
-
Absher, Devin
-
Iribarren, Carlo ...
-
Go, Alan
-
Fortmann, Stephe ...
-
Sidney, Stephen
-
Risch, Neil
-
Tang, Hua
-
Myers, Richard M ...
-
Berger, Klaus
-
Stoll, Monika
-
Shah, Svati H.
-
Thorgeirsson, Gu ...
-
Andersen, Karl
-
Havulinna, Aki S ...
-
Herrera, J. Enri ...
-
Faraday, Nauder
-
Kim, Yoonhee
-
Kral, Brian G.
-
Mathias, Rasika ...
-
Ruczinski, Ingo
-
Suktitipat, Bhoo ...
-
Wilson, Alexande ...
-
Yanek, Lisa R.
-
Becker, Lewis C.
-
Linsel-Nitschke, ...
-
Lieb, Wolfgang
-
Koenig, Inke R.
-
Hengstenberg, Ch ...
-
Fischer, Marcus
-
Stark, Klaus
-
Reinhard, Wibke
-
Winogradow, Jani ...
-
Grassl, Martina
-
Grosshennig, Ani ...
-
Preuss, Michael
-
Schreiber, Stefa ...
-
Wichmann, H-Eric ...
-
Meisinger, Chris ...
-
Yee, Jean
-
Friedlander, Yec ...
-
Do, Ron
-
Meigs, James B.
-
Williams, Gordon
-
Nathan, David M.
-
MacRae, Calum A.
-
Qu, Liming
-
Wilensky, Robert ...
-
Matthai, William ...
-
Qasim, Atif N.
-
Hakonarson, Hako ...
-
Pichard, Augusto ...
-
Kent, Kenneth M.
-
Satler, Lowell
-
Lindsay, Joseph ...
-
Waksman, Ron
-
Knouff, Christop ...
-
Waterworth, Dawn ...
-
Walker, Max C.
-
Mooser, Vincent ...
-
Marrugat, Jaume
-
Lucas, Gavin
-
Subirana, Isaac
-
Sala, Joan
-
Ramos, Rafael
-
Martinelli, Nico ...
-
Olivieri, Olivie ...
-
Trabetti, Elisab ...
-
Malerba, Giovann ...
-
Pignatti, Pier F ...
-
Guiducci, Candac ...
-
Mirel, Daniel
-
Parkin, Melissa
-
Hirschhorn, Joel ...
-
Asselta, Rosanna
-
Duga, Stefano
-
Musunuru, Kiran
-
Daly, Mark J.
-
Purcell, Shaun
-
Eifert, Sandra
-
Braund, Peter S.
-
Wright, Benjamin ...
-
Balmforth, Antho ...
-
Ball, Stephen G.
-
Ouwehand, Willem ...
-
Deloukas, Panos
-
Scholz, Michael
-
Cambien, Francoi ...
-
Huge, Andreas
-
Scheffold, Thoma ...
-
Salomaa, Veikko
-
Girelli, Domenic ...
-
Granger, Christo ...
-
Peltonen, Leena
-
McKeown, Pascal ...
-
Altshuler, David
-
Melander, Olle
-
Devaney, Joseph ...
-
Epstein, Stephen ...
-
Rader, Daniel J.
-
Elosua, Roberto
-
Engert, James C.
-
Anand, Sonia S.
-
Hall, Alistair S ...
-
Ziegler, Andreas
-
O'Donnell, Chris ...
-
Spertus, John A.
-
Siscovick, David
-
Schwartz, Stephe ...
-
Becker, Diane
-
Thorsteinsdottir ...
-
Stefansson, Kari
-
Schunkert, Herib ...
-
Samani, Nilesh J ...
-
Quertermous, Tho ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Journal of the A ...
- By the university
-
Lund University