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Forebrain ependymal...
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
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- Carlen, Marie (author)
- Karolinska Institutet
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- Meletis, Konstantinos (author)
- Karolinska Institutet
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- Goritz, Christian (author)
- Karolinska Institutet
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- Darsalia, Vladimer (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Evergren, Emma (author)
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Tanigaki, Kenji (author)
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Amendola, Mario (author)
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- Barnabe-Heider, Fanie (author)
- Karolinska Institutet
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- Yeung, Maggie S. Y. (author)
- Karolinska Institutet
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Naldini, Luigi (author)
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Honjo, Tasuku (author)
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Kokaia, Zaal (author)
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- Shupliakov, Oleg (author)
- Karolinska Institutet
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Cassidy, Robert M. (author)
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Frisen, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-02-22
- 2009
- English.
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In: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 12:3, s. 259-267
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Abstract
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- Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell cycle and produce olfactory bulb neurons, whereas forced Notch signaling was sufficient to block the ependymal cell response to stroke. Ependymal cells were depleted by stroke and failed to self-renew sufficiently to maintain their own population. Thus, although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Carlen, Marie
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Meletis, Konstan ...
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Goritz, Christia ...
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Darsalia, Vladim ...
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Evergren, Emma
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Tanigaki, Kenji
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show more...
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Amendola, Mario
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Barnabe-Heider, ...
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Yeung, Maggie S. ...
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Naldini, Luigi
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Honjo, Tasuku
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Kokaia, Zaal
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Shupliakov, Oleg
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Cassidy, Robert ...
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Lindvall, Olle
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Frisen, Jonas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Neuroscie ...
- By the university
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Lund University
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Karolinska Institutet