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Common genetic dete...
Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.
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- Sabater-Lleal, Maria (author)
- Karolinska Institutet
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- Mälarstig, Anders (author)
- Karolinska Institutet
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Folkersen, Lasse (author)
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Soler Artigas, María (author)
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Baldassarre, Damiano (author)
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Kavousi, Maryam (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Veglia, Fabrizio (author)
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Brusselle, Guy (author)
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Hofman, Albert (author)
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Franco, Oscar H (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Paulsson-Berne, Gabrielle (author)
- Karolinska Institutet
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Watkins, Hugh (author)
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- Eriksson, Per (author)
- Karolinska Institutet
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Humphries, Steve E (author)
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Tremoli, Elena (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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Tobin, Martin D (author)
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- Hamsten, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-08-05
- 2014
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:8
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http://www.ncbi.nlm....
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Abstract
Subject headings
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- Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung function (spirometry) for association with carotid intima-media thickness (cIMT) in 3,378 subjects with multiple CAD risk factors, and for association with CAD in a case-control study of 5,775 CAD cases and 7,265 controls. SNPs rs2865531, located in the CFDP1 gene, and rs9978142, located in the KCNE2 gene, were significantly associated with CAD. In addition, SNP rs9978142 and SNP rs3995090 located in the HTR4 gene, were associated with average and maximal cIMT measures. Genetic risk scores combining the most robustly spirometry-associated SNPs from the literature were modestly associated with CAD, (odds ratio (OR) (95% confidence interval (CI95) = 1.06 (1.03, 1.09); P-value = 1.5×10-4, per allele). In conclusion, our study suggests that some genetic loci implicated in determining human lung function also influence cIMT and susceptibility to CAD. The present results should help elucidate the molecular underpinnings of the co-morbidity observed across COPD and CAD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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PLoS ONE
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- By the author/editor
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Sabater-Lleal, M ...
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Mälarstig, Ander ...
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Folkersen, Lasse
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Soler Artigas, M ...
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Baldassarre, Dam ...
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Kavousi, Maryam
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show more...
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Almgren, Peter
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Veglia, Fabrizio
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Brusselle, Guy
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Hofman, Albert
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Engström, Gunnar
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Franco, Oscar H
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Melander, Olle
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Paulsson-Berne, ...
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Watkins, Hugh
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Eriksson, Per
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Humphries, Steve ...
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Tremoli, Elena
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de Faire, Ulf
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Tobin, Martin D
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Hamsten, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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PLoS ONE
- By the university
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Lund University
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Karolinska Institutet