Search: onr:"swepub:oai:lup.lub.lu.se:4f1f2780-79aa-4067-8ad2-4e2033f831f7" >
Synthesis of gem-Di...
Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4 + 1] Annulation of Difluorocarbene and Antitumor Activity Evaluation
-
- Zhou, Qianying (author)
- Wuhan University of Technology
-
- Huang, Mi (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
- Shen, Yongcun (author)
- Wuhan University of Technology
-
show more...
-
- Chen, Zhenling (author)
- Guizhou University
-
- Xu, Liying (author)
- Wuhan University
-
- Yang, Zhigang (author)
- Wuhan University
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English 6 s.
-
In: Organic Letters. - 1523-7060. ; 26:6, s. 1212-1217
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF2 source for the construction of gem-difluorinated ring structures. Here, we develop a protocol for the efficient assembly of valuable fluorinated 2,3-dihydrobenzofurans from the [4 + 1] annulation in good yields under basic conditions. The reliable practicability and scalability of the process have also been demonstrated by preparation at the multigram scale, late-stage modifications of pharmaceutical molecules, and potential antitumor potency.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database