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Endothelial basemen...
Endothelial basement membrane laminin alpha 5 selectively inhibits T lymphocyte extravasation into the brain
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Wu, Chuan (author)
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- Ivars, Fredrik (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Anderson, Per (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Hallmann, Rupert (author)
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Vestweber, Dietmar (author)
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Nilsson, Per (author)
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Robenek, Horst (author)
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- Tryggvason, Karl (author)
- Karolinska Institutet
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Song, Jian (author)
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Korpos, Eva (author)
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Loser, Karin (author)
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Beissert, Stefan (author)
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Georges-Labouesse, Elisabeth (author)
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Sorokin, Lydia M. (author)
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(creator_code:org_t)
- 2009-04-26
- 2009
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 15:5, s. 519-527
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Abstract
Subject headings
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- Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte extravasation correlates with sites expressing laminin alpha 4 and small amounts of laminin alpha 5. In mice lacking laminin alpha 4, laminin alpha 5 is ubiquitously expressed along the vascular tree, resulting in marked and selective reduction of T lymphocyte infiltration into the brain and reduced disease susceptibility and severity. Vessel phenotype and immune response were not affected in these mice. Rather, laminin alpha 5 directly inhibited integrin alpha(6)beta(1)-mediated migration of T lymphocytes through laminin alpha 4. The data indicate that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelial basement membrane barrier, permitting specific targeting of this immune cell population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wu, Chuan
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Ivars, Fredrik
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Anderson, Per
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Hallmann, Rupert
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Vestweber, Dietm ...
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Nilsson, Per
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show more...
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Robenek, Horst
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Tryggvason, Karl
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Song, Jian
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Korpos, Eva
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Loser, Karin
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Beissert, Stefan
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Georges-Labouess ...
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Sorokin, Lydia M ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University
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Karolinska Institutet