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  • Bauer, D. C. (author)

Classification of osteoarthritis biomarkers: a proposed approach

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Elsevier BV,2006

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  • LIBRIS-ID:oai:lup.lub.lu.se:502202d7-a36d-4b74-ad0c-a335bbe1c735
  • https://lup.lub.lu.se/record/399365URI
  • https://doi.org/10.1016/j.joca.2006.04.001DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in CA investigations. Conclusion. The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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  • Hunter, D. J. (author)
  • Abramson, S. B. (author)
  • Attur, M. (author)
  • Corr, M. (author)
  • Felson, D. (author)
  • Heinegård, DickLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-dhe (author)
  • Jordan, J. M. (author)
  • Kepler, T. B. (author)
  • Lane, N. E. (author)
  • Saxne, ToreLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-tsa (author)
  • Tyree, B. (author)
  • Kraus, V. B. (author)
  • Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

Related titles

  • In:Osteoarthritis and Cartilage: Elsevier BV14:8, s. 723-7271063-4584

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