Search: onr:"swepub:oai:lup.lub.lu.se:50bd4790-3f30-42b0-b1f8-c5b6ba382042" >
Role of Type 1 diab...
Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study.
-
- Törn, Carina (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
-
- Hadley, David (author)
- University of South Florida
-
- Lee, Hye-Seung (author)
- University of South Florida
-
show more...
-
- Hagopian, William (author)
- Pacific Northwest Research Institute
-
- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
-
- Simell, Olli (author)
- University of Turku
-
- Rewers, Marian (author)
- University of Colorado
-
- Ziegler, Anette (author)
- Helmholtz Zentrum München
-
- Schatz, Desmond (author)
- University of Florida
-
- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
-
- Onengut-Gumuscu, Suna (author)
- University of Virginia
-
- Chen, Wei-Min (author)
- University of Virginia
-
Toppari, Jorma (author)
-
Mykkänen, Juha (author)
-
Ilonen, Jorma (author)
-
Rich, Stephen S (author)
-
She, Jin-Xiong (author)
-
Steck, Andrea K (author)
-
Krischer, Jeffrey (author)
-
show less...
-
(creator_code:org_t)
- 2014-11-24
- 2015
- English.
-
In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 64:5, s. 1818-1829
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
http://dx.doi.org/10...
-
https://diabetes.dia...
-
https://lup.lub.lu.s...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,677 children enrolled from birth, who carry HLA-susceptibility genotypes for development of islet autoantibodies (IA) and type 1 diabetes (T1D). During the median follow-up time of 57 months, 350 children developed at least one persistent IA (GADA, IA-2A or mIAA) and 84 of them progressed to T1D. We genotyped 5,164 Caucasian children for 41 non-HLA SNPs that achieved genome-wide significance for association with T1D in the GWAS meta-analysis conducted by the Type 1 Diabetes Genetics Consortium. In TEDDY-participants carrying high-risk HLA-genotypes, eight SNPs achieved significant association to development of IA using time-to-event analysis (p<0.05), whereof four were significant after adjustment for multiple testing (p<0.0012): rs2476601 in PTPN22 (hazard ratio [HR] 1.54 [95% CI 1.27-1.88]), rs2292239 in ERBB3 (HR 1.33 [95% CI 1.14-1.55]), rs3184504 in SH2B3 (HR 1.38 [95% CI 1.19-1.61]) and rs1004446 in INS (HR 0.77 [0.66-0.90]). These SNPs were also significantly associated with T1D in particular: rs2476601 (HR 2.42 [95% CI 1.70-3.44]). Although genes in the HLA-region remain the most important genetic risk factors for T1D, other non-HLA genetic factors contribute to IA, a first step in the pathogenesis of T1D, and the progression of the disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Törn, Carina
-
Hadley, David
-
Lee, Hye-Seung
-
Hagopian, Willia ...
-
Lernmark, Åke
-
Simell, Olli
-
show more...
-
Rewers, Marian
-
Ziegler, Anette
-
Schatz, Desmond
-
Akolkar, Beena
-
Onengut-Gumuscu, ...
-
Chen, Wei-Min
-
Toppari, Jorma
-
Mykkänen, Juha
-
Ilonen, Jorma
-
Rich, Stephen S
-
She, Jin-Xiong
-
Steck, Andrea K
-
Krischer, Jeffre ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetes
- By the university
-
Lund University