Search: onr:"swepub:oai:lup.lub.lu.se:515fca77-03a2-4228-8ea8-fbaf8d973ab0" >
Prevalence and clin...
Prevalence and clinical correlations of antibodies against six beta 2-glycoprotein-I-related peptides in the antiphospholipid syndrome
-
Shoenfeld, Y (author)
-
Krause, I (author)
-
Kvapil, F (author)
-
show more...
-
Sulkes, J (author)
-
Lev, S (author)
-
von Landenberg, P (author)
-
Font, J (author)
-
Zaech, J (author)
-
Cervera, R (author)
-
Piette, JC (author)
-
Boffa, MC (author)
-
Khamashta, MA (author)
-
Bertolaccini, ML (author)
-
Hughes, GRV (author)
-
Youinou, P (author)
-
Meroni, PL (author)
-
Pengo, V (author)
-
Alves, JD (author)
-
Tincani, A (author)
-
Szegedi, G (author)
-
Lakos, G (author)
-
- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Koike, T (author)
-
Sanmarco, M (author)
-
Ruffatti, A (author)
-
Ulcova-Gallova, Z (author)
-
Praprotnik, S (author)
-
Rozman, B (author)
-
Lorber, M (author)
-
Vriezman, VB (author)
-
Blank, M (author)
-
show less...
-
(creator_code:org_t)
- 2003
- 2003
- English.
-
In: Journal of Clinical Immunology. - 0271-9142. ; 23:5, s. 377-383
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six beta2GPI-related peptides. A high degree of simultaneous reactivity against several beta2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the beta2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- systemic lupus
- antiphospholipid syndrome
- synthetic peptides
- autoimmunity
- erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Shoenfeld, Y
-
Krause, I
-
Kvapil, F
-
Sulkes, J
-
Lev, S
-
von Landenberg, ...
-
show more...
-
Font, J
-
Zaech, J
-
Cervera, R
-
Piette, JC
-
Boffa, MC
-
Khamashta, MA
-
Bertolaccini, ML
-
Hughes, GRV
-
Youinou, P
-
Meroni, PL
-
Pengo, V
-
Alves, JD
-
Tincani, A
-
Szegedi, G
-
Lakos, G
-
Sturfelt, Gunnar
-
Jönsen, Andreas
-
Koike, T
-
Sanmarco, M
-
Ruffatti, A
-
Ulcova-Gallova, ...
-
Praprotnik, S
-
Rozman, B
-
Lorber, M
-
Vriezman, VB
-
Blank, M
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University