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Prevalence and clin...
Prevalence and clinical correlations of antibodies against six beta 2-glycoprotein-I-related peptides in the antiphospholipid syndrome
- Article/chapterEnglish2003
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LIBRIS-ID:oai:lup.lub.lu.se:515fca77-03a2-4228-8ea8-fbaf8d973ab0
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https://lup.lub.lu.se/record/303464URI
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https://doi.org/10.1023/A:1025321617304DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six beta2GPI-related peptides. A high degree of simultaneous reactivity against several beta2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the beta2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.
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Krause, I
(author)
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Kvapil, F
(author)
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Sulkes, J
(author)
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Lev, S
(author)
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von Landenberg, P
(author)
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Font, J
(author)
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Zaech, J
(author)
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Cervera, R
(author)
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Piette, JC
(author)
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Boffa, MC
(author)
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Khamashta, MA
(author)
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Bertolaccini, ML
(author)
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Hughes, GRV
(author)
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Youinou, P
(author)
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Meroni, PL
(author)
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Pengo, V
(author)
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Alves, JD
(author)
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Tincani, A
(author)
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Szegedi, G
(author)
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Lakos, G
(author)
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Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst
(author)
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Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-ajo
(author)
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Koike, T
(author)
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Sanmarco, M
(author)
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Ruffatti, A
(author)
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Ulcova-Gallova, Z
(author)
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Praprotnik, S
(author)
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Rozman, B
(author)
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Lorber, M
(author)
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Vriezman, VB
(author)
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Blank, M
(author)
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
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In:Journal of Clinical Immunology23:5, s. 377-3830271-9142
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Shoenfeld, Y
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Krause, I
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Kvapil, F
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Sulkes, J
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Lev, S
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von Landenberg, ...
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show more...
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Font, J
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Zaech, J
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Cervera, R
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Piette, JC
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Boffa, MC
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Khamashta, MA
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Bertolaccini, ML
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Hughes, GRV
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Youinou, P
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Meroni, PL
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Pengo, V
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Alves, JD
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Tincani, A
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Szegedi, G
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Lakos, G
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Sturfelt, Gunnar
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Jönsen, Andreas
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Koike, T
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Sanmarco, M
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Ruffatti, A
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Ulcova-Gallova, ...
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Praprotnik, S
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Rozman, B
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Lorber, M
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Vriezman, VB
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Blank, M
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