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Epigenome-wide thre...
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC
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- Ji, Xinyu (author)
- Nanjing Medical University
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- Lin, Lijuan (author)
- Nanjing Medical University
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- Fan, Juanjuan (author)
- Nanjing Medical University
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- Li, Yi (author)
- University of Michigan
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- Wei, Yongyue (author)
- Nanjing Medical University,Harvard University
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- Shen, Sipeng (author)
- Nanjing Medical University
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- Su, Li (author)
- Harvard University
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- Shafer, Andrea (author)
- Massachusetts General Hospital
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- Bjaanæs, Maria Moksnes (author)
- Oslo university hospital
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- Karlsson, Anna (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Department of Clinical Sciences, Lund
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- Planck, Maria (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Department of Clinical Sciences, Lund
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Department of Clinical Sciences, Lund
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- Helland, Åslaug (author)
- Oslo university hospital,University of Oslo
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- Esteller, Manel (author)
- Josep Carreras Leukaemia Research Institute (IJC),Catalan Institution for Research and Advanced Studies,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Barcelona
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- Zhang, Ruyang (author)
- Harvard University,Nanjing Medical University
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- Chen, Feng (author)
- Nanjing Medical University
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- Christiani, David C. (author)
- Massachusetts General Hospital,Harvard University
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(creator_code:org_t)
- 2022-01-07
- 2022
- English 15 s.
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In: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 16:3, s. 717-731
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Abstract
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- The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. However, to understand the complex mechanisms underlying NSCLC progression, we searched three-way interactions. A two-phase study was adopted to identify three-way interactions in the form of pack-year of smoking (number of cigarettes smoked per day × number of years smoked) × cg05293407TRIM27 × epigenome-wide DNA methylation CpG probe. Two CpG probes were identified with FDR-q ≤ 0.05 in the discovery phase and P ≤ 0.05 in the validation phase: cg00060500KIAA0226 and cg17479956EXT2. Compared to a prediction model with only clinical information, the model added 42 significant three-way interactions using a looser criterion (discovery: FDR-q ≤ 0.10, validation: P ≤ 0.05) had substantially improved the area under the receiver operating characteristic curve (AUC) of the prognostic prediction model for both 3-year and 5-year survival. Our research identified the complex interaction effects among multiple environment and epigenetic factors, and provided therapeutic target for NSCLC patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Ji, Xinyu
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Lin, Lijuan
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Fan, Juanjuan
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Li, Yi
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Wei, Yongyue
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Shen, Sipeng
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show more...
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Su, Li
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Shafer, Andrea
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Zhang, Ruyang
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Chen, Feng
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Christiani, Davi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Molecular Oncolo ...
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Lund University