onr:"swepub:oai:lup.lub.lu.se:5264f5c9-b5c7-4cc0-9694-ddadd7e0a6a7"
Search: onr:"swepub:oai:lup.lub.lu.se:5264f5c9-b5c7-4cc0-9694-ddadd7e0a6a7" > The STRIPAK Complex...
- 1 of 1
- Previous record
- Next record
- To hitlist
The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27
-
- Rodriguez-Cupello, Carmen (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancer and matrix remodelling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Dam, Monica (author)
- Lund University
-
- Serini, Laura (author)
- Lund University
- show more...
- show less...
- (creator_code:org_t)
- 2020-03-17
- 2020
- English.
- In: Frontiers in cell and developmental biology. - : Frontiers Media SA. - 2296-634X. ; 8
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding protein STRIP1 in cancer cell migration and metastasis. We show that cell cycle arrest and decreased proliferation are seen upon loss of STRIP1 in MDA-MB-231 cells due to the induction of cyclin dependent kinase inhibitors, including p21 and p27. We demonstrate that p21 and p27 induction is observed in a subpopulation of cells having low DNA damage response and that the p21high/γH2AXlow ratio within single cells can be rescued by depleting MST3&4 kinases. While the loss of STRIP1 decreases cell proliferation and tumor growth, cells treated with low dosage of chemotherapeutics in vitro paradoxically escape therapy-induced senescence and begin to proliferate after recovery. This corroborates with already known research on the dual role of p21 and indicates that STRIP1 also plays a contradictory role in breast cancer, suppressing tumor growth, but once treated with chemotherapeutics, allowing for possible recurrence and decreased patient survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Frontiers in cell and developmental biology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Rodriguez-Cupell ...
- Dam, Monica
- Serini, Laura
- Wang, Shan
- Lindgren, David
- Englund, Emelie
- show more...
- Kjellman, Pontus
- Axelson, Håkan
- García Mariscal, ...
- Madsen, Chris
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Frontiers in cel ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
