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In vitro effect of ...
In vitro effect of fibrinogen on Candida albicans germ tube formation
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Rodrigues, A (author)
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Vaz, C P (author)
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- Mårdh, Per-Anders (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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da Fonseca, A F (author)
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de Oliveira, J M (author)
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - 1600-0463. ; 107:11, s. 1020-1022
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated in the presence of serial concentrations of fraction I, type IV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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