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Microbiome connecti...
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
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- Asnicar, Francesco (author)
- University of Trento
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- Berry, Sarah E. (author)
- King's College London
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- Valdes, Ana M. (author)
- University of Nottingham,Nottingham Biomedical Research Centre (BRC)
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- Nguyen, Long H. (author)
- Harvard University,Massachusetts General Hospital
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- Piccinno, Gianmarco (author)
- University of Trento
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- Drew, David A. (author)
- Harvard University,Massachusetts General Hospital
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- Leeming, Emily (author)
- King's College London
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- Gibson, Rachel (author)
- King's College London
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- Le Roy, Caroline (author)
- King's College London
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- Khatib, Haya Al (author)
- Zoe Global Limited
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- Francis, Lucy (author)
- Zoe Global Limited
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- Mazidi, Mohsen (author)
- King's College London
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- Mompeo, Olatz (author)
- King's College London
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- Valles-Colomer, Mireia (author)
- University of Trento
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- Tett, Adrian (author)
- University of Trento
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- Beghini, Francesco (author)
- University of Trento
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- Dubois, Léonard (author)
- University of Trento
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- Bazzani, Davide (author)
- University of Trento
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- Thomas, Andrew Maltez (author)
- University of Trento
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- Mirzayi, Chloe (author)
- City University of New York
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- Khleborodova, Asya (author)
- City University of New York
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- Oh, Sehyun (author)
- City University of New York
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- Hine, Rachel (author)
- Zoe Global Limited
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- Bonnett, Christopher (author)
- Zoe Global Limited
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- Capdevila, Joan (author)
- Zoe Global Limited
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- Danzanvilliers, Serge (author)
- Zoe Global Limited
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- Giordano, Francesca (author)
- Zoe Global Limited
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- Geistlinger, Ludwig (author)
- City University of New York
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- Waldron, Levi (author)
- City University of New York
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- Davies, Richard (author)
- Zoe Global Limited
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- Hadjigeorgiou, George (author)
- Zoe Global Limited
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- Wolf, Jonathan (author)
- Zoe Global Limited
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- Ordovás, José M. (author)
- Tufts University,Autonomous University of Madrid
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- Gardner, Christopher (author)
- Stanford University
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Chan, Andrew T. (author)
- Massachusetts General Hospital,Harvard University,Broad Institute
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- Huttenhower, Curtis (author)
- Harvard University,Broad Institute
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- Spector, Tim D. (author)
- King's College London
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- Segata, Nicola (author)
- European Institute of Oncology,University of Trento
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(creator_code:org_t)
- 2021-01-11
- 2021
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:2, s. 321-332
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Asnicar, Frances ...
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Berry, Sarah E.
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Valdes, Ana M.
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Nguyen, Long H.
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Piccinno, Gianma ...
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Drew, David A.
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show more...
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Leeming, Emily
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Gibson, Rachel
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Le Roy, Caroline
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Khatib, Haya Al
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Francis, Lucy
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Mazidi, Mohsen
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Mompeo, Olatz
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Valles-Colomer, ...
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Tett, Adrian
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Beghini, Frances ...
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Dubois, Léonard
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Bazzani, Davide
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Thomas, Andrew M ...
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Mirzayi, Chloe
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Khleborodova, As ...
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Oh, Sehyun
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Hine, Rachel
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Bonnett, Christo ...
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Capdevila, Joan
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Danzanvilliers, ...
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Giordano, France ...
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Geistlinger, Lud ...
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Waldron, Levi
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Davies, Richard
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Hadjigeorgiou, G ...
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Wolf, Jonathan
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Ordovás, José M.
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Gardner, Christo ...
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Franks, Paul W.
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Chan, Andrew T.
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Huttenhower, Cur ...
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Spector, Tim D.
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Segata, Nicola
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University