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Vascular effects of helodermin, helospectin I and helospectin II : a comparison with vasoactive intestinal peptide (VIP)
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- Grundemar, L (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Högestätt, E D (author)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
- (creator_code:org_t)
- 2012-07-19
- 1990
- English.
- In: British Journal of Pharmacology. - : Wiley. - 0007-1188. ; 99:3, s. 526-528
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- 1. Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat. 2. They all reduced blood pressure in a dose-dependent manner; helodermin was less effective than VIP. However, at doses higher than 1 nmol kg-1 all four peptides reduced blood pressure to about the same extent. 3. The half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins. 4. VIP and helodermin were equally potent in relaxing femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha. 5. Helospectin I and II relaxed phenylephrine-contracted vessels to the same extent as VIP but with a lower potency. 6. Addition of VIP 1 microM to preparations exposed to helodermin 1 microM or to either of the helospectins did not produce a further relaxation. 7. The findings indicate that VIP, helodermin and helospectin I and II have a similar profile of action and therefore may act on a common receptor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Amino Acid Sequence
- Animals
- Blood Pressure/drug effects
- Dinoprost/pharmacology
- Female
- Half-Life
- Hemodynamics/drug effects
- In Vitro Techniques
- Male
- Molecular Sequence Data
- Peptides/pharmacology
- Phenylephrine/pharmacology
- Rats
- Rats, Inbred Strains
- Vasoactive Intestinal Peptide/pharmacology
Publication and Content Type
- art (subject category)
- ref (subject category)
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