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Lipidomic profiles,...
Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes
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- Varga, Tibor V (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,University of Copenhagen
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- Ali, Ashfaq (author)
- National Bioinformatics Infrastructure Sweden (NBIS), SciLifeLab,Steno Diabetes Center Copenhagen
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- Herrera, Jose A R (author)
- University of Copenhagen
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- Ahonen, Linda L (author)
- Biosyntia ApS
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- Mattila, Ismo M (author)
- Steno Diabetes Center Copenhagen
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- Al-Sari, Naba H (author)
- Steno Diabetes Center Copenhagen
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- Legido-Quigley, Cristina (author)
- King's College London
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- Skouby, Sven (author)
- Herlev Hospital
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- Brunak, Søren (author)
- University of Copenhagen
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- Tornberg, Åsa B (author)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Människan i rörelse: hälsa och rehabilitering,Child and Family Health,Lund University Research Groups,Human Movement: health and rehabilitation
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(creator_code:org_t)
- 2020-02-11
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10, s. 1-9
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Abstract
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- We assessed whether blood lipid metabolites and their changes associate with various cardiometabolic, endocrine, bone- and energy-related comorbidities of Relative Energy Deficiency in Sport (RED-S) in female elite endurance athletes. Thirty-eight Scandinavian female elite athletes underwent a day-long exercise test. Five blood samples were obtained during the day - at fasting state and before and after two standardized exercise tests. Clinical biomarkers were assessed at fasting state, while untargeted lipidomics was undertaken using all blood samples. Linear and logistic regression was used to assess associations between lipidomic features and clinical biomarkers. Overrepresentations of findings with P < 0.05 from these association tests were assessed using Fisher's exact tests. Self-organizing maps and a trajectory clustering algorithm were utilized to identify informative clusters in the population. Twenty associations PFDR < 0.05 were detected between lipidomic features and clinical biomarkers. Notably, cortisol demonstrated an overrepresentation of associations with P < 0.05 compared to other traits (PFisher = 1.9×10-14). Mean lipid trajectories were created for 201 named features for the cohort and subsequently by stratifying participants by their energy availability and menstrual dysfunction status. This exploratory analysis of lipid trajectories indicates that participants with menstrual dysfunction might have decreased adaptive response to exercise interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Varga, Tibor V
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Ali, Ashfaq
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Herrera, Jose A ...
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Ahonen, Linda L
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Mattila, Ismo M
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Al-Sari, Naba H
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show more...
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Legido-Quigley, ...
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Skouby, Sven
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Brunak, Søren
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Tornberg, Åsa B
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Lund University