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Lower vitamin D lev...
Lower vitamin D levels are associated with depression among community-dwelling European men
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Lee, David M. (author)
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Tajar, Abdelouahid (author)
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O'Neill, Terence W. (author)
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O'Connor, Daryl B. (author)
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Bartfai, Gyorgy (author)
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Boonen, Steven (author)
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Bouillon, Roger (author)
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Casanueva, Felipe F. (author)
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Finn, Joseph D. (author)
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Forte, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S. (author)
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Huhtaniemi, Ilpo T. (author)
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Kula, Krzysztof (author)
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Lean, Michael E. J. (author)
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Punab, Margus (author)
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Silman, Alan J. (author)
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Vanderschueren, Dirk (author)
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Wu, Frederick C. W. (author)
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Pendleton, Neil (author)
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(creator_code:org_t)
- 2010-09-07
- 2011
- English.
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In: Journal of Psychopharmacology. - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 25:10, s. 1320-1328
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p < 0.001) and PTH higher (p = 0.004) in people with depression. In age- and centre-adjusted linear regressions a higher BDI-II score was significantly associated with tower levels of 25(OH)D (p = 0.004). After adjustment for lifestyle and health factors this relationship was attenuated but remained significant (p = 0.01). Using multivariable logistic regression the odds for depression increased approximately 70% across decreasing 25(OH)D quartiles (p(trend) = 0.04). There was no independent association between PIN and depression in any of the muttivariable regressions. Our results reveal an inverse association between 25(OH)D levels and depression, largely independent of several lifestyle and health factors. Further studies are required to determine whether higher levels of vitamin D have an antidepressant effect in older adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Ageing
- depression
- male health
- parathyroid hormone
- population
- survey
- vitamin D
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lee, David M.
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Tajar, Abdelouah ...
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O'Neill, Terence ...
-
O'Connor, Daryl ...
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Bartfai, Gyorgy
-
Boonen, Steven
-
show more...
-
Bouillon, Roger
-
Casanueva, Felip ...
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Finn, Joseph D.
-
Forte, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S.
-
Huhtaniemi, Ilpo ...
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Kula, Krzysztof
-
Lean, Michael E. ...
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Punab, Margus
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Silman, Alan J.
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Vanderschueren, ...
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Wu, Frederick C. ...
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Pendleton, Neil
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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Journal of Psych ...
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Lund University