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Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain
- Bassant, M H (author)
-
- Joly, M (author)
- National Institute for Health and Medical Research, France
-
- Nilsson, O G (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Lamour, Y (author)
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- (creator_code:org_t)
- Elsevier BV, 1988
- 1988
- English.
- In: Brain Research. - : Elsevier BV. - 0006-8993. ; 460:1, s. 8-16
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Acetylcholine/pharmacology
- Animals
- Brain/physiology
- Carbachol/pharmacology
- Electrophysiology/methods
- Glutamates/pharmacology
- Glutamic Acid
- Male
- Nerve Tissue/transplantation
- Neurons/drug effects
- Neurotransmitter Agents/pharmacology
- Norepinephrine/pharmacology
- Rats
- Rats, Inbred Strains
- Reference Values
- Serotonin/pharmacology
- gamma-Aminobutyric Acid/pharmacology
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Bassant, M H
- Joly, M
- Nilsson, O G
- Björklund, A
- Lamour, Y
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Brain Research
- By the university
- Lund University
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