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Short and long-term associations between serum proteins linked to cardiovascular disease and particle exposure among constructions workers
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- Gliga, Anda R. (author)
- Karolinska Institutet,Karolinska Institute
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- Grahn, Karin (author)
- Karolinska Institutet,Karolinska Institute
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- Gustavsson, Per (author)
- Karolinska Institutet,Karolinska Institute
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- (creator_code:org_t)
- 2022-11-21
- 2023
- English 10 s.
- In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 49:2, s. 145-154
- Journal article (peer-reviewed)
Abstract
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- Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we measured 92 serum proteins linked to CVD among active male construction workers (N=65, non-smokers) sampled on two occasions: during work and after vacation. First, we used linear models to identify short-term changes in proteins associated with particle exposure (assessed as respirable dust and RCS) during work. Secondly, we used linear mixed models to evaluate whether these associations were long-term, ie, persistent after vacation. Results The median exposure to respirable dust and RCS during work were 0.25 mg/m3 and 0.01 mg/m3, respec-tively. Respirable dust was associated with short-term changes in six proteins (tissue factor, growth hormone, heme oxygenase-1, dickkopf-related protein-1, platelet-derived growth factor-B, stem cell factor); long-term associations were observed for the former three proteins. RCS was associated with short-term changes in five proteins (carcinoembryonic antigen-related cell adhesion molecule-8, hydroxyacid oxidase-1, tissue factor, car-bonic anhydrase-5A, lectin-like oxidized LDL receptor-1); long-term associations were observed for the former four proteins. Conclusions Moderate exposure to particles in the construction industry is associated with both short-and long-term changes in circulating CVD-related proteins. Further studies are needed to evaluate if these changes are predictors of occupationally induced clinical CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- biomarker
- cardiovascular biomarker
- occupational exposure
- respirable crystalline silica
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Gliga, Anda R.
- Grahn, Karin
- Gustavsson, Per
- Ljungman, Petter
- Albin, Maria
- Selander, Jenny
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- Broberg, Karin
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- MEDICAL AND HEALTH SCIENCES
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- Lund University
- Karolinska Institutet
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