SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:558c21dd-97ca-4bac-bbff-c4612faef84a"
 

Search: onr:"swepub:oai:lup.lub.lu.se:558c21dd-97ca-4bac-bbff-c4612faef84a" > Identification of s...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Jonsson, StefandeCODE Genetics (author)

Identification of sequence variants influencing immunoglobulin levels

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-06-19
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:558c21dd-97ca-4bac-bbff-c4612faef84a
  • https://lup.lub.lu.se/record/558c21dd-97ca-4bac-bbff-c4612faef84aURI
  • https://doi.org/10.1038/ng.3897DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and influence blood cell development. Notable associations include a rare variant at RUNX3 decreasing IgA levels by shifting isoform proportions (rs188468174[C>T]: P = 8.3 × 10(-55), β = -0.90 s.d.), a rare in-frame deletion in FCGR2B abolishing IgG binding to the encoded receptor (p.Asn106del: P = 4.2 × 10(-8), β = 1.03 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA region. Our results provide new insight into the regulation of humoral immunity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sveinbjornsson, GardardeCODE Genetics (author)
  • de Lapuente Portilla, Aitzkoa LopezLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-azl (author)
  • Swaminathan, BhairaviLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-bvs (author)
  • Plomp, RosinaLeiden University Medical Centre (author)
  • Dekkers, GillianUniversity of Amsterdam (author)
  • Ajore, RamLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-rao (author)
  • Ali, MinaLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-ma16 (author)
  • Bentlage, Arthur E HUniversity of Amsterdam (author)
  • Elmér, EvelinaLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)gerd-eie (author)
  • Eyjolfsson, Gudmundur IngiLaboratory in Mjodd, Reykjavik (author)
  • Gudjonsson, Sigurjon A.deCODE Genetics (author)
  • Gullberg, UrbanLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)efor-ugu (author)
  • Gylfason, ArnaldurdeCODE Genetics (author)
  • Halldorsson, Bjarni V.Reykjavik University (author)
  • Hansson, MarkusLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Myelomgruppen,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Myeloma research group,Lund University Research Groups(Swepub:lu)hema-mha (author)
  • Holm, HilmadeCODE Genetics (author)
  • Johansson, ÅsaLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)infl-ajo (author)
  • Johnsson, EllinorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)efor-ejo (author)
  • Jonasdottir, AslaugdeCODE Genetics (author)
  • Ludviksson, Bjorn RNational University Hospital of Iceland (author)
  • Oddsson, AsmundurdeCODE Genetics (author)
  • Olafsson, IsleifurNational University Hospital of Iceland (author)
  • Olafsson, SigurgeirdeCODE Genetics (author)
  • Sigurdardottir, OlofUniversity of Iceland (author)
  • Sigurdsson, AsgeirdeCODE Genetics (author)
  • Stefansdottir, LiljadeCODE Genetics (author)
  • Masson, GislideCODE Genetics (author)
  • Sulem, PatrickdeCODE Genetics (author)
  • Wuhrer, ManfredLeiden University Medical Centre (author)
  • Wihlborg, Anna-KarinLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)kard-awi (author)
  • Thorleifsson, GudmardeCODE Genetics (author)
  • Gudbjartsson, Daniel F.University of Iceland (author)
  • Thorsteinsdottir, UnnurUniversity of Iceland (author)
  • Vidarsson, GesturUniversity of Amsterdam (author)
  • Jonsdottir, IngileifUniversity of Iceland (author)
  • Nilsson, BjörnLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Broad Institute(Swepub:lu)klin-bni (author)
  • Stefansson, KariUniversity of Iceland (author)
  • deCODE GeneticsAvdelningen för hematologi och transfusionsmedicin (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC49:8, s. 1182-11911546-17181061-4036

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view