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A toxicological and...
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients
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Belsito, D. (author)
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Bickers, D. (author)
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- Bruze, Magnus (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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Calow, P. (author)
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Dagli, M. L. (author)
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Fryer, A. D. (author)
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Greim, H. (author)
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Miyachi, Y. (author)
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Saurath, J. H. (author)
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Sipes, I. G. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915. ; 50, s. 52-99
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- The aryl alkyl alcohol (AAA) fragrance ingredients are a diverse group of chemical structures with similar metabolic and toxicity profiles. The AAA fragrances demonstrate low acute and subchronic dermal and oral toxicity. No carcinogenicity in rats or mice was observed in 2-year chronic testing of benzyl alcohol or alpha-methylbenzyl alcohol: the latter did induce species and gender-specific renal adenomas in male rats at the high dose. There was no to little genotoxicity, mutagenicity, or clastogenicity in the mutagenic in vitro bacterial assays, and in vitro mammalian cell assays. All in vivo micronucleus assays were negative. NOAELs for maternal and developmental toxicity are far in excess of current human exposure levels. At concentrations likely to be encountered by consumers, AAA fragrance ingredients are non-irritating to the skin. The potential for eye irritation is minimal. With the exception of benzyl alcohol and to a lesser extent phenethyl and 2-phenoxyethyl AAA alcohols, human sensitization studies, diagnostic patch tests and human induction studies, indicate that AAA fragrance ingredients generally have no or low sensitization potential. Available data indicate that the potential for photosensitization is low. It is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients. (c) 2011 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Fragrance ingredients
- Aryl alkyl alcohols
- Safety review
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- ref (subject category)
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- By the author/editor
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Belsito, D.
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Bickers, D.
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Bruze, Magnus
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Calow, P.
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Dagli, M. L.
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Fryer, A. D.
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show more...
-
Greim, H.
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Miyachi, Y.
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Saurath, J. H.
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Sipes, I. G.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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Food and Chemica ...
- By the university
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Lund University