Search: onr:"swepub:oai:lup.lub.lu.se:55c08a87-7fa3-434a-8886-b46460dc7268" >
Genome-wide analysi...
-
Helgadottir, AnnadeCODE Genetics
(author)
Genome-wide analysis yields new loci associating with aortic valve stenosis
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2018-03-07
-
Springer Science and Business Media LLC,2018
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:55c08a87-7fa3-434a-8886-b46460dc7268
-
https://lup.lub.lu.se/record/55c08a87-7fa3-434a-8886-b46460dc7268URI
-
https://doi.org/10.1038/s41467-018-03252-6DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137799962URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10-22) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10-13). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10-10) and aortic root diameter (P = 1.30 × 10-8), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10-3) and coronary artery disease (OR = 1.05, P = 9.3 × 10-5). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Thorleifsson, GudmardeCODE Genetics
(author)
-
Gretarsdottir, SolveigdeCODE Genetics
(author)
-
Stefansson, Olafur A.deCODE Genetics
(author)
-
Tragante, ViniciusdeCODE Genetics
(author)
-
Thorolfsdottir, Rosa B.deCODE Genetics
(author)
-
Jonsdottir, IngileifdeCODE Genetics,University of Iceland
(author)
-
Bjornsson, ThorsteinndeCODE Genetics
(author)
-
Steinthorsdottir, ValgerdurdeCODE Genetics
(author)
-
Verweij, NiekUniversity Medical Center Groningen,Broad Institute
(author)
-
Nielsen, Jonas B.University of Michigan
(author)
-
Zhou, WeiUniversity of Michigan
(author)
-
Folkersen, LasseKarolinska University Hospital,Technical University of Denmark
(author)
-
Martinsson, AndreasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-asm
(author)
-
Heydarpour, MahyarBrigham and Women's Hospital / Harvard Medical School
(author)
-
Prakash, SiddharthUniversity of Texas
(author)
-
Oskarsson, GylfiNational University Hospital of Iceland(Swepub:lu)extLU-265
(author)
-
Gudbjartsson, TomasNational University Hospital of Iceland
(author)
-
Geirsson, ArnarYale University
(author)
-
Olafsson, IsleifurNational University Hospital of Iceland
(author)
-
Sigurdsson, Emil L.University of Iceland
(author)
-
Almgren, PeterLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital(Swepub:lu)endo-pal
(author)
-
Melander, OlleLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome
(author)
-
Franco-Cereceda, AndersKarolinska Institutet,Karolinska University Hospital
(author)
-
Hamsten, AndersKarolinska Institutet,Karolinska University Hospital
(author)
-
Fritsche, LarsNorwegian University of Science and Technology
(author)
-
Lin, MaoxuanUniversity of Michigan
(author)
-
Yang, BoUniversity of Michigan
(author)
-
Hornsby, WhitneyUniversity of Michigan
(author)
-
Guo, DongchuanUniversity of Texas
(author)
-
Brummett, Chad M.University of Michigan
(author)
-
Abecasis, GonçaloUniversity of Michigan
(author)
-
Mathis, MichaelUniversity of Michigan
(author)
-
Milewicz, DiannaTexas Heart Institute,University of Texas
(author)
-
Body, Simon C.Brigham and Women's Hospital / Harvard Medical School
(author)
-
Eriksson, PerKarolinska Institutet,Karolinska University Hospital
(author)
-
Willer, Cristen J.University of Michigan
(author)
-
Hveem, KristianNorwegian University of Science and Technology
(author)
-
Newton-Cheh, ChristopherBroad Institute,Massachusetts General Hospital
(author)
-
Smith, J. GustavLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-gvs
(author)
-
Danielsen, RagnarNational University Hospital of Iceland
(author)
-
Thorgeirsson, GudmundurNational University Hospital of Iceland,deCODE Genetics,University of Iceland
(author)
-
Thorsteinsdottir, UnnurdeCODE Genetics,University of Iceland
(author)
-
Gudbjartsson, Daniel F.deCODE Genetics,University of Iceland
(author)
-
Holm, HilmadeCODE Genetics
(author)
-
Stefansson, KariUniversity of Iceland,deCODE Genetics
(author)
-
deCODE GeneticsUniversity of Iceland
(creator_code:org_t)
Related titles
-
In:Nature Communications: Springer Science and Business Media LLC9:12041-1723
Internet link
Find in a library
To the university's database
- By the author/editor
-
Helgadottir, Ann ...
-
Thorleifsson, Gu ...
-
Gretarsdottir, S ...
-
Stefansson, Olaf ...
-
Tragante, Vinici ...
-
Thorolfsdottir, ...
-
show more...
-
Jonsdottir, Ingi ...
-
Bjornsson, Thors ...
-
Steinthorsdottir ...
-
Verweij, Niek
-
Nielsen, Jonas B ...
-
Zhou, Wei
-
Folkersen, Lasse
-
Martinsson, Andr ...
-
Heydarpour, Mahy ...
-
Prakash, Siddhar ...
-
Oskarsson, Gylfi
-
Gudbjartsson, To ...
-
Geirsson, Arnar
-
Olafsson, Isleif ...
-
Sigurdsson, Emil ...
-
Almgren, Peter
-
Melander, Olle
-
Franco-Cereceda, ...
-
Hamsten, Anders
-
Fritsche, Lars
-
Lin, Maoxuan
-
Yang, Bo
-
Hornsby, Whitney
-
Guo, Dongchuan
-
Brummett, Chad M ...
-
Abecasis, Gonçal ...
-
Mathis, Michael
-
Milewicz, Dianna
-
Body, Simon C.
-
Eriksson, Per
-
Willer, Cristen ...
-
Hveem, Kristian
-
Newton-Cheh, Chr ...
-
Smith, J. Gustav
-
Danielsen, Ragna ...
-
Thorgeirsson, Gu ...
-
Thorsteinsdottir ...
-
Gudbjartsson, Da ...
-
Holm, Hilma
-
Stefansson, Kari
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Communica ...
- By the university
-
Lund University
-
Karolinska Institutet