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TNF-α and α-synucle...
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
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- Russ, Kaspar (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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- Teku, Gabriel (author)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Bousset, Luc (author)
- François Jacob Institute of biology
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- Redeker, Virginie (author)
- François Jacob Institute of biology
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- Piel, Sara (author)
- Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
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- Savchenko, Ekaterina (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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- Pomeshchik, Yuriy (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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- Savistchenko, Jimmy (author)
- François Jacob Institute of biology
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- Stummann, Tina C. (author)
- H. Lundbeck A/S
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- Azevedo, Carla (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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- Collin, Anna (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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- Goldwurm, Stefano (author)
- Istituto Ortopedico Gaetano Pini
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- Fog, Karina (author)
- H. Lundbeck A/S
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- Elmer, Eskil (author)
- Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
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- Vihinen, Mauno (author)
- Lund University,Lunds universitet,Proteinbioinformatik,Forskargrupper vid Lunds universitet,Protein Bioinformatics,Lund University Research Groups
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- Melki, Ronald (author)
- François Jacob Institute of biology
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- Roybon, Laurent (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 34:12
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
Close
- Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- alpha-synuclein
- astrocytes
- HLA genes
- iPSC
- Parkinson's disease
- reactivity
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Russ, Kaspar
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Teku, Gabriel
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Bousset, Luc
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Redeker, Virgini ...
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Piel, Sara
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Savchenko, Ekate ...
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show more...
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Pomeshchik, Yuri ...
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Savistchenko, Ji ...
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Stummann, Tina C ...
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Azevedo, Carla
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Collin, Anna
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Goldwurm, Stefan ...
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Fog, Karina
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Elmer, Eskil
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Vihinen, Mauno
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Melki, Ronald
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Roybon, Laurent
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Lund University