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TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Russ, Kaspar (author)
Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
Teku, Gabriel (author)
Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
Bousset, Luc (author)
François Jacob Institute of biology
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Redeker, Virginie (author)
François Jacob Institute of biology
Piel, Sara (author)
Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
Savchenko, Ekaterina (author)
Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
Pomeshchik, Yuriy (author)
Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
Savistchenko, Jimmy (author)
François Jacob Institute of biology
Stummann, Tina C. (author)
H. Lundbeck A/S
Azevedo, Carla (author)
Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
Collin, Anna (author)
Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
Goldwurm, Stefano (author)
Istituto Ortopedico Gaetano Pini
Fog, Karina (author)
H. Lundbeck A/S
Elmer, Eskil (author)
Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
Vihinen, Mauno (author)
Lund University,Lunds universitet,Proteinbioinformatik,Forskargrupper vid Lunds universitet,Protein Bioinformatics,Lund University Research Groups
Melki, Ronald (author)
François Jacob Institute of biology
Roybon, Laurent (author)
Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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 (creator_code:org_t)
Elsevier BV, 2021
2021
English.
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 34:12
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

alpha-synuclein
astrocytes
HLA genes
iPSC
Parkinson's disease
reactivity

Publication and Content Type

art (subject category)
ref (subject category)

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