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Early recognition a...
Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease : Protocol of the BEAT-IT study
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- Eikelboom, Willem S. (author)
- Erasmus University Medical Center
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- Singleton, Ellen (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Van Den Berg, Esther (author)
- Erasmus University Medical Center
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- Coesmans, Michiel (author)
- Erasmus University Medical Center
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- Mattace Raso, Francesco (author)
- Erasmus University Medical Center
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- Van Bruchem, Rozemarijn L. (author)
- Erasmus University Medical Center
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- Goudzwaard, Jeannette A. (author)
- Erasmus University Medical Center
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- De Jong, Frank Jan (author)
- Erasmus University Medical Center
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- Koopmanschap, Marc (author)
- Erasmus University Rotterdam
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- Den Heijer, Tom (author)
- Franciscus Gasthuis & Vlietland
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- Driesen, Jan J.M. (author)
- Franciscus Gasthuis & Vlietland
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- Vroegindeweij, Lilian J.H.M. (author)
- Van Weel-Bethesda Hospital
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- Thomeer, Elsbeth C. (author)
- Maasstad Ziekenhuis
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- Hoogers, Susanne E. (author)
- Spijkenisse Medical Center
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- Dijkstra, Anke A. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Zuidema, Sytse U. (author)
- University Medical Center Groningen
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- Pijnenburg, Yolande A.L. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Van Swieten, John C. (author)
- Erasmus University Medical Center
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Papma, Janne M. (author)
- Erasmus University Medical Center
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(creator_code:org_t)
- 2019-05-24
- 2019
- English.
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In: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 11:1
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Abstract
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- Background: Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and are associated with various disadvantageous clinical outcomes including a negative impact on quality of life, caregiver burden, and accelerated disease progression. Despite growing evidence of the efficacy of (non)pharmacological interventions to reduce these symptoms, NPS remain underrecognized and undertreated in memory clinics. The BEhavioural symptoms in Alzheimer's disease Towards early Identification and Treatment (BEAT-IT) study is developed to (1) investigate the neurobiological etiology of NPS in AD and (2) study the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) approach to structure and standardize the current care of NPS in AD. By means of the DICE method, we aim to improve the quality of life of AD patients with NPS and their caregivers who visit the memory clinic. This paper describes the protocol for the intervention study that incorporates the latter aim. Methods: We aim to enroll a total of 150 community-dwelling patients with MCI or AD and their caregivers in two waves. First, we will recruit a control group who will receive care as usual. Next, the second wave of participants will undergo the DICE method. This approach consists of the following steps: (1) describe the context in which NPS occur, (2) investigate the possible causes, (3) create and implement a treatment plan, and (4) evaluate whether these interventions are effective. Primary outcomes are the quality of life of patients and their caregivers. Secondary outcomes include NPS change, caregiver burden, caregivers' confidence managing NPS, psychotropic medication use, the experiences of patients and caregivers who underwent the DICE method, and the cost-effectiveness of the intervention. Conclusions: This paper describes the protocol of an intervention study that is part of the BEAT-IT study and aims to improve current recognition and treatment of NPS in AD by structuring and standardizing the detection and treatment of NPS in AD using the DICE approach. Trial registration: The trial was registered on the Netherlands Trial Registry (NTR7459); registered 6 September 2018.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Alzheimer's disease
- Behavior
- Caregivers
- Cost-benefit analysis
- Dementia
- Neuropsychiatry
- Prospective studies
- Quality of life
Publication and Content Type
- art (subject category)
- ref (subject category)
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Eikelboom, Wille ...
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Singleton, Ellen
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Van Den Berg, Es ...
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Coesmans, Michie ...
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Mattace Raso, Fr ...
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Van Bruchem, Roz ...
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Goudzwaard, Jean ...
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De Jong, Frank J ...
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Koopmanschap, Ma ...
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Den Heijer, Tom
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Driesen, Jan J.M ...
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Vroegindeweij, L ...
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Thomeer, Elsbeth ...
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Hoogers, Susanne ...
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Dijkstra, Anke A ...
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Zuidema, Sytse U ...
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Pijnenburg, Yola ...
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Scheltens, Phili ...
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Van Swieten, Joh ...
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Ossenkoppele, Ri ...
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Papma, Janne M.
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MEDICAL AND HEAL ...
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Alzheimer's Rese ...
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Lund University