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Botulinum and tetan...
Botulinum and tetanus neurotoxins
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- Dong, Min (author)
- Boston Children's Hospital,Harvard Medical School
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- Masuyer, Geoffrey (author)
- Stockholms universitet,Stockholm University,Institutionen för biokemi och biofysik
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- Stenmark, Pål (author)
- Stockholms universitet,Stockholm University,Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Strukturell biokemi,Developmental and Regenerative Neurobiology,Lund University Research Groups,Structural Biochemistry,Institutionen för biokemi och biofysik,Lund University, Sweden
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(creator_code:org_t)
- Annual Reviews, 2019
- 2019
- English 27 s.
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In: Annual Review of Biochemistry. - : Annual Reviews. - 0066-4154 .- 1545-4509. ; 88, s. 811-837
- Related links:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- bacterial toxin
- botulinum neurotoxin
- clostridium
- protein engineering
- tetanus neurotoxin
- toxin
- botulinum neurotoxin
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