Search: onr:"swepub:oai:lup.lub.lu.se:56025bdc-d24f-4d9d-9f68-a72d0465ce8a" >
Matrix Redox Physio...
-
Møller, Ian MaxAarhus University
(author)
Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2020-01-06
-
Oxford University Press (OUP),2020
-
22 s.
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:56025bdc-d24f-4d9d-9f68-a72d0465ce8a
-
https://lup.lub.lu.se/record/56025bdc-d24f-4d9d-9f68-a72d0465ce8aURI
-
https://doi.org/10.1105/tpc.19.00535DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:for swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Mitochondria function as hubs of plant metabolism. Oxidative phosphorylation produces ATP, but it is also a central high-capacity electron sink required by many metabolic pathways that must be flexibly coordinated and integrated. Here, we review the crucial roles of redox-associated posttranslational protein modifications (PTMs) in mitochondrial metabolic regulation. We discuss several major concepts. First, the major redox couples in the mitochondrial matrix (NAD, NADP, thioredoxin, glutathione, and ascorbate) are in kinetic steady state rather than thermodynamic equilibrium. Second, targeted proteomics have produced long lists of proteins potentially regulated by Cys oxidation/thioredoxin, Met-SO formation, phosphorylation, or Lys acetylation, but we currently only understand the functional importance of a few of these PTMs. Some site modifications may represent molecular noise caused by spurious reactions. Third, different PTMs on the same protein or on different proteins in the same metabolic pathway can interact to fine-tune metabolic regulation. Fourth, PTMs take part in the repair of stress-induced damage (e.g., by reducing Met and Cys oxidation products) as well as adjusting metabolic functions in response to environmental variation, such as changes in light irradiance or oxygen availability. Finally, PTMs form a multidimensional regulatory system that provides the speed and flexibility needed for mitochondrial coordination far beyond that provided by changes in nuclear gene expression alone.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Igamberdiev, Abir U.Memorial University of Newfoundland
(author)
-
Bykova, Natalia V.Agriculture and Agri-Food Canada (AAFC)
(author)
-
Finkemeier, IrisUniversity of Münster
(author)
-
Rasmusson, Allan G.Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)fysb-ara
(author)
-
Schwarzländer, MarkusUniversity of Münster
(author)
-
Aarhus UniversityMemorial University of Newfoundland
(creator_code:org_t)
Related titles
-
In:The Plant cell: Oxford University Press (OUP)32:3, s. 573-5941040-46511532-298X
Internet link
Find in a library
To the university's database