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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003408naa a2200409 4500
001oai:lup.lub.lu.se:56e47593-546c-4dfe-ba92-2a1ae9c5006c
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/29949242 URI
0247 a https://doi.org/10.1038/jid.2012.1042 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Li, Jian4 aut
2451 0a Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities
264 1b Elsevier BV,c 2012
520 a Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with squamous cell carcinomas (SCCs). Furthermore, there are reports of KAs that have metastasized, invoking the question of whether KA is a variant of SCC (Hodak et al., 1993). To date, no reported criteria are sensitive enough to discriminate reliably between KA and SCC, and consequently there is a clinical need for discriminating markers. Our previous study analyzed 132 KAs and 29 SCCs and revealed significantly different regions of genomic aberrations using chromosomal comparative genomic hybridization (CGH). In the present study, we applied array CGH to investigate 98 KAs and 22 SCCs from the above samples. The result shows that all KAs and SCCs have some degree of genetic aberrations. The distribution of numbers of aberrant clones per sample differed significantly between KAs and SCCs (P<0.02), which also demonstrated recurrent aberrations that differed significantly (P<0.001), as illustrated by unsupervised cluster analysis. Classifiers for clinicopathological parameters of KAs were established based on t-test statistics and permutation tests. Tumor size, fibrosis, and inflammation, which are related to the developmental stages of KAs, showed significant (t-test, permutation test) associations with aberrations of selected genomic regions. This suggests chromosomal instability during the whole life cycle of KAs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
7001 a Wang, Kai4 aut
7001 a Gao, Fei4 aut
7001 a Jensen, Thomas D.4 aut
7001 a Li, Shengting T.4 aut
7001 a DeAngelis, Paula M.4 aut
7001 a Kolvraa, Steen4 aut
7001 a Proby, Charlotte4 aut
7001 a Forslund, Olau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-ofo
7001 a Bolund, Lars4 aut
7001 a Clausen, Ole Petter F.4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Investigative Dermatologyd : Elsevier BVg 132:8, s. 2060-2066q 132:8<2060-2066x 1523-1747x 0022-202X
8564 u http://dx.doi.org/10.1038/jid.2012.104y FULLTEXT
8564 u http://www.jidonline.org/article/S0022202X1535836X/pdf
8564 8u https://lup.lub.lu.se/record/2994924
8564 8u https://doi.org/10.1038/jid.2012.104

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