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Second malignancies...
Second malignancies in multiple myeloma; emerging patterns and future directions
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- Maclachlan, Kylee (author)
- Memorial Sloan-Kettering Cancer Center
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- Diamond, Benjamin (author)
- Memorial Sloan-Kettering Cancer Center
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- Maura, Francesco (author)
- Memorial Sloan-Kettering Cancer Center
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- Hillengass, Jens (author)
- Roswell Park Cancer Institute
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Landgren, C. Ola (author)
- Memorial Sloan-Kettering Cancer Center
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- Kazandjian, Dickran (author)
- National Cancer Institute, USA
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Best Practice and Research: Clinical Haematology. - : Elsevier BV. - 1521-6926. ; 33:1
- Related links:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The changing landscape of treatment options for multiple myeloma has led to a higher proportion of patients achieving deep, long-lasting responses to therapy. With the associated improvement in overall survival, the development of subsequent second malignancies has become of increased significance. The risk of second malignancy after multiple myeloma is affected by a combination of patient-, disease- and therapy-related risk factors. This review discusses recent data refining our knowledge of these contributing factors, including current treatment modalities which increase risk (i.e. high-dose melphalan with autologous stem cell transplant and lenalidomide maintenance therapy). We highlight emerging data towards individualized risk- and response-adapted treatment strategies and discuss key areas requiring future research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Autologous
- Lenalidomide
- Melphalan
- Multiple myeloma
- Neoplasms
- Risk factors
- Second primary
- Transplantation
Publication and Content Type
- for (subject category)
- ref (subject category)
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