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TIGER : The gene ex...
TIGER : The gene expression regulatory variation landscape of human pancreatic islets
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- Alonso, Lorena (author)
- Centro Nacional de Supercomputación
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- Piron, Anthony (author)
- Université Libre de Bruxelles (ULB)
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- Morán, Ignasi (author)
- Centro Nacional de Supercomputación
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- Guindo-Martínez, Marta (author)
- Centro Nacional de Supercomputación
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- Bonàs-Guarch, Sílvia (author)
- Barcelona Institute of Science and Technology
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- Atla, Goutham (author)
- Barcelona Institute of Science and Technology
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- Miguel-Escalada, Irene (author)
- Barcelona Institute of Science and Technology
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- Royo, Romina (author)
- Centro Nacional de Supercomputación
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- Puiggròs, Montserrat (author)
- Centro Nacional de Supercomputación
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- Garcia-Hurtado, Xavier (author)
- Barcelona Institute of Science and Technology
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- Suleiman, Mara (author)
- University of Pisa
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- Marselli, Lorella (author)
- University of Pisa
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- Esguerra, Jonathan L S (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Turatsinze, Jean-Valéry (author)
- Université Libre de Bruxelles (ULB)
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- Torres, Jason M (author)
- University of Oxford
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Nylander, Vibe (author)
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- Chen, Ji (author)
- University of Exeter
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- Eliasson, Lena (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Defrance, Matthieu (author)
- Université Libre de Bruxelles (ULB)
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- Amela, Ramon (author)
- Centro Nacional de Supercomputación
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- Mulder, Hindrik (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Gloyn, Anna L (author)
- Stanford Diabetes Research Centre
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)
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- Marchetti, Piero (author)
- University of Pisa
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Eizirik, Decio L (author)
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- Ferrer, Jorge (author)
- Barcelona Institute of Science and Technology
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- Mercader, Josep M (author)
- Broad Institute
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Cnop, Miriam (author)
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- Torrents, David (author)
- Centro Nacional de Supercomputación
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 37:2
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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Abstract
Subject headings
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- Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes using four reference panels and meta-analyze cohorts to improve the coverage of expression quantitative trait loci (eQTL) and develop a method to combine allele-specific expression across samples (cASE). We identify >1 million islet eQTLs, 53 of which colocalize with T2D signals. Among them, a low-frequency allele that reduces T2D risk by half increases CCND2 expression. We identify eight cASE colocalizations, among which we found a T2D-associated SLC30A8 variant. We make all data available through the TIGER portal (http://tiger.bsc.es), which represents a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translates into therapeutic insight and precision medicine for T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Alonso, Lorena
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Piron, Anthony
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Morán, Ignasi
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Guindo-Martínez, ...
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Bonàs-Guarch, Sí ...
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Atla, Goutham
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show more...
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Miguel-Escalada, ...
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Royo, Romina
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Puiggròs, Montse ...
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Garcia-Hurtado, ...
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Suleiman, Mara
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Marselli, Lorell ...
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Esguerra, Jonath ...
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Turatsinze, Jean ...
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Torres, Jason M
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Nylander, Vibe
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Chen, Ji
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Eliasson, Lena
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Defrance, Matthi ...
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Amela, Ramon
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Mulder, Hindrik
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Gloyn, Anna L
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Groop, Leif
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Marchetti, Piero
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Eizirik, Decio L
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Ferrer, Jorge
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Mercader, Josep ...
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Cnop, Miriam
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Torrents, David
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Cell Reports
- By the university
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Lund University