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TIGER : The gene ex...
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Alonso, LorenaCentro Nacional de Supercomputación
(author)
TIGER : The gene expression regulatory variation landscape of human pancreatic islets
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:59af1f95-4fad-47cc-8239-8adbb9999bfa
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https://lup.lub.lu.se/record/59af1f95-4fad-47cc-8239-8adbb9999bfaURI
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https://doi.org/10.1016/j.celrep.2021.109807DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes using four reference panels and meta-analyze cohorts to improve the coverage of expression quantitative trait loci (eQTL) and develop a method to combine allele-specific expression across samples (cASE). We identify >1 million islet eQTLs, 53 of which colocalize with T2D signals. Among them, a low-frequency allele that reduces T2D risk by half increases CCND2 expression. We identify eight cASE colocalizations, among which we found a T2D-associated SLC30A8 variant. We make all data available through the TIGER portal (http://tiger.bsc.es), which represents a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translates into therapeutic insight and precision medicine for T2D.
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Piron, AnthonyUniversité Libre de Bruxelles (ULB)
(author)
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Morán, IgnasiCentro Nacional de Supercomputación
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Guindo-Martínez, MartaCentro Nacional de Supercomputación
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Bonàs-Guarch, SílviaBarcelona Institute of Science and Technology
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Atla, GouthamBarcelona Institute of Science and Technology
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Miguel-Escalada, IreneBarcelona Institute of Science and Technology
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Royo, RominaCentro Nacional de Supercomputación
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Puiggròs, MontserratCentro Nacional de Supercomputación
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Garcia-Hurtado, XavierBarcelona Institute of Science and Technology
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Suleiman, MaraUniversity of Pisa
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Marselli, LorellaUniversity of Pisa
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Esguerra, Jonathan L SLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)med-jer
(author)
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Turatsinze, Jean-ValéryUniversité Libre de Bruxelles (ULB)
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Torres, Jason MUniversity of Oxford
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Nylander, Vibe
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Chen, JiUniversity of Exeter
(author)
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Eliasson, LenaLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)mphy-lel
(author)
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Defrance, MatthieuUniversité Libre de Bruxelles (ULB)
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Amela, RamonCentro Nacional de Supercomputación
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Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-hmu
(author)
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Gloyn, Anna LStanford Diabetes Research Centre
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)endo-lgr
(author)
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Marchetti, PieroUniversity of Pisa
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Eizirik, Decio L
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Ferrer, JorgeBarcelona Institute of Science and Technology
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Mercader, Josep MBroad Institute
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Cnop, Miriam
(author)
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Torrents, DavidCentro Nacional de Supercomputación
(author)
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Centro Nacional de SupercomputaciónUniversité Libre de Bruxelles (ULB)
(creator_code:org_t)
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Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
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In:Cell Reports: Elsevier BV37:22211-1247
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Alonso, Lorena
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Piron, Anthony
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Morán, Ignasi
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Guindo-Martínez, ...
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Bonàs-Guarch, Sí ...
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Atla, Goutham
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Miguel-Escalada, ...
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Royo, Romina
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Puiggròs, Montse ...
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Garcia-Hurtado, ...
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Suleiman, Mara
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Marselli, Lorell ...
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Esguerra, Jonath ...
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Turatsinze, Jean ...
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Torres, Jason M
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Nylander, Vibe
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Chen, Ji
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Eliasson, Lena
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Defrance, Matthi ...
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Amela, Ramon
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Mulder, Hindrik
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Gloyn, Anna L
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Groop, Leif
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Marchetti, Piero
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Eizirik, Decio L
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Ferrer, Jorge
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Mercader, Josep ...
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Cnop, Miriam
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Torrents, David
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