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Interaction of diab...
Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme
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- Raghavan, Sridharan (author)
- VA Eastern Colorado Health Care System,University of Colorado,Colorado School of Public Health
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- Jablonski, Kathleen (author)
- George Washington University
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- Delahanty, Linda M. (author)
- Harvard University,Massachusetts General Hospital
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- Maruthur, Nisa M. (author)
- Johns Hopkins University
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- Leong, Aaron (author)
- Harvard University,Massachusetts General Hospital
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Knowler, William C. (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Florez, Jose C. (author)
- Harvard University,Massachusetts General Hospital,Broad Institute
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- Dabelea, Dana (author)
- Colorado School of Public Health
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(creator_code:org_t)
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- 2021-01-29
- 2021
- English.
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In: Diabetes, Obesity and Metabolism. - : Wiley. - 1462-8902 .- 1463-1326. ; 23:4, s. 1030-1040
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Abstract
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- Aim: To test whether diabetes genetic risk modifies the association of successful lifestyle changes with incident diabetes. Materials and methods: We studied 823 individuals randomized to the intensive lifestyle intervention (ILS) arm of the Diabetes Prevention Programme who were diabetes-free 1 year after enrolment. We tested additive and multiplicative interactions of a 67-variant diabetes genetic risk score (GRS) with achievement of three ILS goals at 1 year (≥7% weight loss, ≥150 min/wk of moderate leisure-time physical activity, and/or a goal for self-reported total fat intake) on the primary outcome of incident diabetes over 3 years of follow-up. Results: A lower GRS and achieving each or all three ILS goals were each associated with lower incidence of diabetes (all P < 0.05). Additive interactions were significant between the GRS and achievement of the weight loss goal (P < 0.001), physical activity goal (P = 0.02), and all three ILS goals (P < 0.001) for diabetes risk. Achievement of all three ILS goals was associated with 1.8 (95% CI 0.3, 3.4), 3.1 (95% CI 1.5, 4.7), and 3.9 (95% CI 1.6, 6.2) fewer diabetes cases/100-person-years in the first, second and third GRS tertiles (P < 0.001 for trend). Multiplicative interactions between the GRS and ILS goal achievement were significant for the diet goal (P < 0.001), but not for weight loss (P = 0.18) or physical activity (P = 0.62) goals. Conclusions: Genetic risk may identify high-risk subgroups for whom successful lifestyle modification is associated with greater absolute reduction in the risk of incident diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Raghavan, Sridha ...
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Jablonski, Kathl ...
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Delahanty, Linda ...
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Maruthur, Nisa M ...
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Leong, Aaron
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Franks, Paul W.
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show more...
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Knowler, William ...
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Florez, Jose C.
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Dabelea, Dana
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Diabetes, Obesit ...
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Lund University