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Dynamic changes in ...
Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
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- Brænne, Ingrid (author)
- University of Virginia School of Medicine
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- Onengut-Gumuscu, Suna (author)
- University of Virginia School of Medicine,University of Virginia
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- Chen, Ruoxi (author)
- University of Virginia School of Medicine
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- Kero, Jukka (author)
- University of Turku,Turku University Hospital
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- Kähönen, Miia (author)
- Oulu University Hospital,University of Oulu
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- Koivikko, Minna Liisa (author)
- Oulu University Hospital,University of Oulu
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- Ollikainen, Paula (author)
- Oulu University Hospital,University of Oulu
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- Tossavainen, Päivi (author)
- Oulu University Hospital,University of Oulu
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- Veijola, Riitta (author)
- Oulu University Hospital,University of Oulu
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- Viinikangas, Irene (author)
- Oulu University Hospital,University of Oulu
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- Lernmark, Åke (author)
- Lund University,Lunds universitet
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- Agardh, Daniel (author)
- Lund University,Lunds universitet
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- Aronsson, Carin Andrén (author)
- Lund University,Lunds universitet
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- Ask, Maria (author)
- Lund University,Lunds universitet
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- Bennet, Rasmus (author)
- Lund University,Lunds universitet
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- Cilio, Corrado (author)
- Lund University,Lunds universitet
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- Engqvist, Helene (author)
- Lund University,Lunds universitet
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- Ericson-Hallström, Emelie (author)
- Lund University,Lunds universitet
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- Fransson, Lina (author)
- Lund University,Lunds universitet
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- Gard, Thomas (author)
- Lund University,Lunds universitet
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- Hansen, Monika (author)
- Lund University,Lunds universitet
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- Jisser, Hanna (author)
- Lund University,Lunds universitet
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- Johansen, Fredrik (author)
- Lund University,Lunds universitet
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- Jonsdottir, Berglind (author)
- Lund University,Lunds universitet
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- Jovic, Silvija (author)
- Lund University,Lunds universitet
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- Larsson, Helena Elding (author)
- Lund University,Lunds universitet
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- Lindström, Marielle (author)
- Lund University,Lunds universitet
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- Lundgren, Markus (author)
- Lund University,Lunds universitet
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- Maziarz, Marlena (author)
- Lund University,Lunds universitet
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- Månsson-Martinez, Maria (author)
- Lund University,Lunds universitet
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- Markan, Maria (author)
- Lund University,Lunds universitet
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- Mestan, Zeliha (author)
- Lund University,Lunds universitet
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- Nilsson, Caroline (author)
- Lund University,Lunds universitet
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- Ottosson, Karin (author)
- Lund University,Lunds universitet
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- Rahmati, Kobra (author)
- Lund University,Lunds universitet
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- Ramelius, Anita (author)
- Lund University,Lunds universitet
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- Salami, Falastin (author)
- Lund University,Lunds universitet
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- Sjöberg, Anette (author)
- Lund University,Lunds universitet
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- Sjöberg, Birgitta (author)
- Lund University,Lunds universitet
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- Svensson, Malin (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Törn, Carina (author)
- Lund University,Lunds universitet
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- Wallin, Anne (author)
- Lund University,Lunds universitet
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- Wimar, Åsa (author)
- Lund University,Lunds universitet
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- Åberg, Sofie (author)
- Lund University,Lunds universitet
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- Li, Qian (author)
- University of South Florida
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- Lynch, Kristian (author)
- University of South Florida
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- Parikh, Hemang (author)
- University of South Florida
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- Vehik, Kendra (author)
- University of South Florida
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- Liu, Haitao (author)
- Lund University,Lunds universitet,Lunds lasercentrum, LLC,Annan verksamhet, LTH,Lunds Tekniska Högskola,Lund Laser Centre, LLC,Other operations, LTH,Faculty of Engineering, LTH
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- Johnson, Suzanne Bennett (author)
- Florida State University
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- 2021-11-22
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular interactions in physiologic networks. To test this hypothesis, we utilized longitudinal blood transcriptomic profiles in The Environmental Determinants of Diabetes in the Young (TEDDY) study to generate gene co-expression networks. In network modules that contain immune response genes associated with T1D, we observed highly dynamic differences in module connectivity in the 600 days (~ 2 years) preceding clinical diagnosis of T1D. Our results suggest that gene co-expression is highly plastic and that connectivity differences in T1D-associated immune system genes influence the timing and development of clinical disease.
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Brænne, Ingrid
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Onengut-Gumuscu, ...
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Chen, Ruoxi
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Kero, Jukka
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Kähönen, Miia
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Koivikko, Minna ...
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show more...
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Ollikainen, Paul ...
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Tossavainen, Päi ...
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Veijola, Riitta
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Viinikangas, Ire ...
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Lernmark, Åke
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Agardh, Daniel
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Aronsson, Carin ...
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Ask, Maria
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Bennet, Rasmus
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Cilio, Corrado
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Engqvist, Helene
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Ericson-Hallströ ...
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Fransson, Lina
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Gard, Thomas
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Hansen, Monika
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Jisser, Hanna
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Johansen, Fredri ...
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Jonsdottir, Berg ...
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Jovic, Silvija
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Larsson, Helena ...
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Lindström, Marie ...
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Lundgren, Markus
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Maziarz, Marlena
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Månsson-Martinez ...
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Markan, Maria
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Mestan, Zeliha
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Nilsson, Carolin ...
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Ottosson, Karin
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Rahmati, Kobra
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Ramelius, Anita
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Salami, Falastin
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Sjöberg, Anette
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Sjöberg, Birgitt ...
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Svensson, Malin
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Törn, Carina
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Wallin, Anne
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Wimar, Åsa
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Åberg, Sofie
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Li, Qian
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Lynch, Kristian
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Parikh, Hemang
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Vehik, Kendra
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Liu, Haitao
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Johnson, Suzanne ...
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show less...
- Articles in the publication
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Scientific Repor ...
- By the university
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Lund University