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Neuropathological f...
Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2 : preliminary findings
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- Granholm, Ann-Charlotte E (author)
- University of Colorado at Denver Anschutz Medical Campus
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- Englund, Elisabet (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gilmore, Anah (author)
- University of Colorado at Denver Anschutz Medical Campus
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- Head, Elizabeth (author)
- University of California, Irvine
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- Yong, William H (author)
- University of California, Irvine
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- Perez, Sylvia E (author)
- Barrow Neurological Institute, Phoenix
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- Guzman, Samuel J (author)
- University of Colorado at Denver Anschutz Medical Campus
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- Hamlett, Eric D (author)
- Medical University of South Carolina
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- Mufson, Elliott J (author)
- Barrow Neurological Institute, Phoenix
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Acta Neuropathologica. - 1432-0533. ; 147, s. 1-21
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Abstract
Subject headings
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- The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality risk for people with Alzheimer's disease (AD) and/or Down syndrome (DS). However, few studies have evaluated the neuropathological and inflammatory sequelae in postmortem brain tissue obtained from AD and people with DS with severe SARS-CoV-2 infections. We examined tau, beta-amyloid (Aβ), inflammatory markers and SARS-CoV-2 nucleoprotein in DS, AD, and healthy non-demented controls with COVID-19 and compared with non-infected brain tissue from each disease group (total n = 24). A nested ANOVA was used to determine regional effects of the COVID-19 infection on arborization of astrocytes (Sholl analysis) and percent-stained area of Iba-1 and TMEM 119. SARS-CoV-2 antibodies labeled neurons and glial cells in the frontal cortex of all subjects with COVID-19, and in the hippocampus of two of the three DS COVID-19 cases. SARS-CoV-2-related alterations were observed in peri-vascular astrocytes and microglial cells in the gray matter of the frontal cortex, hippocampus, and para-hippocampal gyrus. Bright field microscopy revealed scattered intracellular and diffuse extracellular Aβ deposits in the hippocampus of controls with confirmed SARS-CoV-2 infections. Overall, the present preliminary findings suggest that SARS-CoV-2 infections induce abnormal inflammatory responses in Down syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Humans
- Down Syndrome/pathology
- Alzheimer Disease/pathology
- COVID-19/pathology
- Male
- Female
- Aged
- Middle Aged
- Brain/pathology
- Aged, 80 and over
- Astrocytes/pathology
- Amyloid beta-Peptides/metabolism
- SARS-CoV-2/pathogenicity
- Microglia/pathology
- Adult
- tau Proteins/metabolism
Publication and Content Type
- art (subject category)
- ref (subject category)
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