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Antiplatelet antibo...
Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia
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- Guo, L. (author)
- University of Toronto,University of Utah,Saint Michael's Hospital
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- Kapur, R. (author)
- Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups,Canadian Blood Services,Saint Michael's Hospital,University of Toronto
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- Aslam, R. (author)
- Saint Michael's Hospital
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- Hunt, K. (author)
- Saint Michael's Hospital
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- Hou, Y. (author)
- Saint Michael's Hospital
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- Zufferey, A. (author)
- Saint Michael's Hospital
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- Speck, E. R. (author)
- Saint Michael's Hospital
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- Rondina, M. T. (author)
- University of Utah
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- Lazarus, A. H. (author)
- University of Toronto,Saint Michael's Hospital
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- Ni, H. (author)
- Saint Michael's Hospital,University of Toronto
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- Semple, J. W. (author)
- Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups,Saint Michael's Hospital,Canadian Blood Services,University of Toronto
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(creator_code:org_t)
- 2018-06-25
- 2018
- English.
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In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475. ; 88:1
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased peripheral immune platelet destruction and megakaryocyte defects in the bone marrow. Although ITP was originally thought to be primarily due to antibody-mediated autoimmunity, it is now clear that T cells also play a significant role in the disease. However, the exact interplay between platelet destruction, megakaryocyte dysfunction and the elements of both humoral and cell-mediated immunity in ITP remains incompletely defined. While most studies have focused on immune platelet destruction in the spleen, an additional possibility is that the antiplatelet antibodies can also destroy bone marrow megakaryocytes. To address this, we negated the effects of T cells by utilizing an in vivo passive ITP model where BALB/c mice were administered various anti-αIIb, anti-β3 or anti-GPIb antibodies or antisera and platelet counts and bone marrow megakaryocytes were enumerated. Our results show that after 24 hours, all the different antiplatelet antibodies/sera induced variable degrees of thrombocytopenia in recipient mice. Compared with naïve control mice, however, histological examination of the bone marrow revealed that only 2 antibody preparations (mouse-anti-mouse β3 sera and an anti- αIIb monoclonal antibody (MWReg30) could affect bone marrow megakaryocyte counts. Our study shows that while most antiplatelet antibodies induce acute thrombocytopenia, the majority of them do not affect the number of megakaryocytes in the bone marrow. This suggests that other mechanisms may be responsible for megakaryocyte abnormalities seen during immune thrombocytopenia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- antibodies/immunoglobulins
- autoantibodies
- autoimmunity
- blood
- experimental animals
- molecules
- phagocytosis
- processes
- subject
- tissues
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Guo, L.
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Kapur, R.
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Aslam, R.
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Hunt, K.
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Hou, Y.
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Zufferey, A.
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show more...
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Speck, E. R.
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Rondina, M. T.
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Lazarus, A. H.
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Ni, H.
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Semple, J. W.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Lund University