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B regulatory cells ...
B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10
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Strom, Asa C. (author)
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Cross, Amanda J. (author)
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Cole, Jennifer E. (author)
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Blair, Paul A. (author)
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Leib, Christoph (author)
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Goddard, Michael E. (author)
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Rosser, Elizabeth C. (author)
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Park, Inhye (author)
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Nilsson, Anna Hultgardh (author)
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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Mauri, Claudia (author)
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Monaco, Claudia (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Thrombosis and Haemostasis. - 0340-6245. ; 114:4, s. 835-847
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Whilst innate B1-B cells are atheroprotective, adaptive B2-B cells are considered pro-atherogenic. Different subsets of B regulatory cells (B-reg) have been described. In experimental arthritis and lupus-like disease, B-reg are contained within the CD21(hi)CD23(hi)CD24(hi) B cell pool The existence and role of B-reg in vascular disease is not known. We sought to investigate the existence, identity and location of B-reg in vascular disease. The representation of B2-B cell subsets in the spleens and lymph nodes (LNs) of Apolipoprotein E-/- (ApoE(-/-)) mice compared to controls was characterised by flow cytometry. Additionally, we utilised a model of neointima formation based on the placement of a perivascular collar around the carotid artery in ApoE(-/-) mice to ascertain whether B cells and B cell subsets confer protection against lesion development. Adoptive transfer of B cells was performed from wild type or genetically modified mice. We showed that CD21(hi)CD23(hi)CD24(hi) B cells are unexpectedly increased in the draining LNs of ApoE(-/-) mice. Adoptive transfer of LN-derived B2-B cells or purified CD21(hi)CD23(hi)CD24(hi) B cells to syngeneic mice reduced lesion size and inflammation without changing serum cholesterol levels. Follicular B2-B cells did not confer protection. IL-10 blockade or transfer of IL10-deficient B cells prevented LN-derived B cell-mediated protection. This is the first identification of a specific LN-derived B2-B-reg subset that confers IL-10 mediated protection from neointima formation. This may open the way for immune modulatory approaches in cardiovascular disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Immunity
- B regulatory cells
- interleukins
- atherosclerosis
- vascular
- disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Strom, Asa C.
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Cross, Amanda J.
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Cole, Jennifer E ...
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Blair, Paul A.
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Leib, Christoph
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Goddard, Michael ...
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show more...
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Rosser, Elizabet ...
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Park, Inhye
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Nilsson, Anna Hu ...
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Nilsson, Jan
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Mauri, Claudia
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Monaco, Claudia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Thrombosis and H ...
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Lund University