Search: onr:"swepub:oai:lup.lub.lu.se:5c6f4e38-1f83-4892-a4e0-357e0aac1eff" >
2-Aminoadipic acid ...
2-Aminoadipic acid is a biomarker for diabetes risk
-
Wang, Thomas J. (author)
-
Ngo, Debby (author)
-
Psychogios, Nikolaos (author)
-
show more...
-
Dejam, Andre (author)
-
Larson, Martin G. (author)
-
Vasan, Ramachandran S. (author)
-
Ghorbani, Anahita (author)
-
O'Sullivan, John (author)
-
Cheng, Susan (author)
-
Rhee, Eugene P. (author)
-
Sinha, Sumita (author)
-
McCabe, Elizabeth (author)
-
Fox, Caroline S. (author)
-
O'Donnell, Christopher J. (author)
-
Ho, Jennifer E. (author)
-
Florez, Jose C. (author)
-
- Magnusson, Martin (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Pierce, Kerry A. (author)
-
Souza, Amanda L. (author)
-
Yu, Yi (author)
-
Carter, Christian (author)
-
Light, Peter E. (author)
-
- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Clish, Clary B. (author)
-
Gerszten, Robert E. (author)
-
show less...
-
(creator_code:org_t)
- 2013
- 2013
- English.
-
In: Journal of Clinical Investigation. - 0021-9738. ; 123:10, s. 4309-4317
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://dx.doi.org/10... (free)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Improvements in metabolite-profiling techniques are providing increased breadth of coverage of the human metabolome and may highlight biomarkers and pathways in common diseases such as diabetes. Using a metabolomics platform that analyzes intermediary organic acids, purines, pyrimidines, and other compounds, we performed a nested case-control study of 188 individuals who developed diabetes and 188 propensity-matched controls from 2,422 normoglycemic participants followed for 12 years in the Framingham Heart Study. The metabolite 2-aminoadipic acid (2-AAA) was most strongly associated with the risk of developing diabetes. Individuals with 2-AAA concentrations in the top quartile had greater than a 4-fold risk of developing diabetes. Levels of 2-AAA were not well correlated with other metabolite biomarkers of diabetes, such as branched chain amino acids and aromatic amino acids, suggesting they report on a distinct pathophysiological pathway. In experimental studies, administration of 2-AAA lowered fasting plasma glucose levels in mice fed both standard chow and high-fat diets. Further, 2-AAA treatment enhanced insulin secretion from a pancreatic beta cell line as well as murine and human islets. These data highlight a metabolite not previously associated with diabetes risk that is increased up to 12 years before the onset of overt disease. Our findings suggest that 2-AAA is a marker of diabetes risk and a potential modulator of glucose homeostasis in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wang, Thomas J.
-
Ngo, Debby
-
Psychogios, Niko ...
-
Dejam, Andre
-
Larson, Martin G ...
-
Vasan, Ramachand ...
-
show more...
-
Ghorbani, Anahit ...
-
O'Sullivan, John
-
Cheng, Susan
-
Rhee, Eugene P.
-
Sinha, Sumita
-
McCabe, Elizabet ...
-
Fox, Caroline S.
-
O'Donnell, Chris ...
-
Ho, Jennifer E.
-
Florez, Jose C.
-
Magnusson, Marti ...
-
Pierce, Kerry A.
-
Souza, Amanda L.
-
Yu, Yi
-
Carter, Christia ...
-
Light, Peter E.
-
Melander, Olle
-
Clish, Clary B.
-
Gerszten, Robert ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University