Search: onr:"swepub:oai:lup.lub.lu.se:5c8018e5-1c9b-4fca-82cc-bdd5c2bc7eef" >
The rate of brain d...
The rate of brain death and organ donation in patients resuscitated from cardiac arrest : a systematic review and meta-analysis
-
- Sandroni, Claudio (author)
- Catholic University of the Sacred Heart, Rome
-
- D’Arrigo, Sonia (author)
- Catholic University of the Sacred Heart, Rome
-
- Callaway, Clifton W. (author)
- University of Pittsburgh
-
show more...
-
- Cariou, Alain (author)
- Paris Descartes University
-
- Dragancea, Irina (author)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups
-
- Taccone, Fabio Silvio (author)
- Université Libre de Bruxelles (ULB)
-
- Antonelli, Massimo (author)
- Catholic University of the Sacred Heart, Rome
-
show less...
-
(creator_code:org_t)
- 2016-10-03
- 2016
- English 11 s.
-
In: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 42:11, s. 1661-1671
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://link.springe...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: The occurrence of brain death in patients with hypoxic-ischaemic brain injury after resuscitation from cardiac arrest creates opportunities for organ donation. However, its prevalence is currently unknown. Methods: Systematic review. MEDLINE via PubMed, ISI Web of Science and the Cochrane Database of Systematic Reviews were searched for eligible studies (2002–2016). The prevalence of brain death in adult patients resuscitated from cardiac arrest and the rate of organ donation among brain dead patients were summarised using a random effect model with double-arcsine transformation. The quality of evidence (QOE) was evaluated according to the GRADE guidelines. Results: 26 studies [16 on conventional cardiopulmonary resuscitation (c-CPR), 10 on extracorporeal CPR (e-CPR)] included a total of 23,388 patients, 1830 of whom developed brain death at a mean time of 3.2 ± 0.4 days after recovery of circulation. The overall prevalence of brain death among patients who died before hospital discharge was 12.6 [10.2–15.2] %. Prevalence was significantly higher in e-CPR vs. c-CPR patients (27.9 [19.7–36.6] vs. 8.3 [6.5–10.4] %; p < 0.0001). The overall rate of organ donation among brain dead patients was 41.8 [20.2–51.0] % (9/26 studies, 1264 patients; range 0–100 %). The QOE was very low for both outcomes. Conclusions: In patients with hypoxic-ischaemic brain injury following CPR, more than 10 % of deaths were due to brain death. More than 40 % of brain-dead patients could donate organs. Patients who are unconscious after resuscitation from cardiac arrest, especially when resuscitated using e-CPR, should be carefully screened for signs of brain death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Anoxia-ischemia, brain
- Brain death
- Cardiac arrest
- Organ donation
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database